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Pretreatment with acivicin affected the fractional distribution profile of <jats:sup>203<\/jats:sup>Hg, resulting in a twofold decrease in the renal incorporation of mercury 4 h posttreatment and a threefold increase in the 24\u2010h urinary excretion of mercury. Plasma radioactivity remained constant over 24 h in rats dosed with <jats:sup>203<\/jats:sup>Hg alone, whereas it decreased by 60% between 4 h and 24 h in \u03b3\u2010GT\u2010inhibited rats. In \u03b3\u2010GT\u2010inhibited rats treated with HgCl<jats:sub>2<\/jats:sub> the renal and plasma reduced glutathione (GSH) content increased by 68% and 330% respectively, as compared to controls. The \u03b3\u2010GT inhibition affected the distribution profile of mercury within urinary proteins, shifting the binding of mercury from the inghmolecular\u2010weight fraction (3% against 80%) to the low\u2010molecular\u2010weight fraction (72% against 10%). A significant but less impressive shift of mercury from the ingh\u2010 to the low\u2010molecular\u2010weight fraction also arose in the plasma.<\/jats:p><jats:p>These results taken together support the pivotal role of extracellular GSH and membrane\u2010bound \u03b3\u2010GT in the renal incorporation, toxicity and excretion of inorganic mercury in rats.<\/jats:p>","DOI":"10.1002\/jat.2550140310","type":"journal-article","created":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T04:43:31Z","timestamp":1160973811000},"page":"201-206","source":"Crossref","is-referenced-by-count":45,"title":["Role of extracellular glutathione and \u03b3\u2010Glutamyltranspeptidase in the disposition and kidney toxicity of inorganic mercury in rats"],"prefix":"10.1002","volume":"14","author":[{"given":"J.","family":"De Ceaurriz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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