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Furthermore, it has been determined that cytosolic glutathione <jats:italic>S<\/jats:italic>\u2010transferase (GST) activity was decreased and glutathione peroxidase (GSH\u2010Px) activity remained unchanged. On the other hand, a decrease in liver microsomal lipid peroxide levels and an increase in GST and GSH\u2010Px activity has been observed. We concluded that decreased lipid peroxide levels in microsomes could be a consequence of increased GSH\u2010Px and GST enzyme activities. In this way, these glutathione\u2010related defence enzyme systems may play an important role in protecting microsomes from lipid peroxidation.<\/jats:p>","DOI":"10.1002\/jat.2550140410","type":"journal-article","created":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T05:04:35Z","timestamp":1160975075000},"page":"297-299","source":"Crossref","is-referenced-by-count":26,"title":["Liver lipid peroxidation and glutathione\u2010related defence enzyme systems in mice treated with paracetamol"],"prefix":"10.1002","volume":"14","author":[{"given":"G\u00fcl","family":"\u00d6zdemirler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcl\u00e7in","family":"Ayka\u00e7","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00fcjdat","family":"Uysal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hikmet","family":"\u00d6z","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(87)90040-2"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(87)80131-7"},{"key":"e_1_2_1_4_2","first-page":"179","article-title":"General mechanism of toxic liver injury with special refernce to free radical reactions","volume":"6","author":"Cheesman K. 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