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The review included use of the oxime alone, oxime plus atropine and oxime plus atropine plus diazepam, given therapeutically, i.e. after nerve agent, in all cases. Experiments with any of these compounds given prophylactically were not considered. The review also included protocols of pyridostigmine prophylaxis and oxime\u2010atropine therapy (with or without diazepam). It was difficult to draw conclusions as to the best oxime to use, because of lack of data in many cases. The identity of the oxime did not appear to be important when pyridostigmine prophylaxis was combined with atropine\u2010oxime\u2010diazepam therapy; in these cases, very good protection was observed in guinea pigs against all four nerve agents. The choice of oxime based on the data presently available may well depend on factors other than protection against lethality, such as cost and availability of the oxime and human toxicity of the oxime. This last factor was also reviewed, and the results showed that toxogonin is likely to cause more side\u2010effects than PAM or HI\u20106. The efficacy of the oximes against the emerging threat agent GF was also reviewed.<\/jats:p>","DOI":"10.1002\/jat.2550140502","type":"journal-article","created":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T04:55:38Z","timestamp":1160974538000},"page":"317-331","source":"Crossref","is-referenced-by-count":269,"title":["Review of oximes available for treatment of nerve agent poisoning"],"prefix":"10.1002","volume":"14","author":[{"given":"R. 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