{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:48:28Z","timestamp":1760575708916,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":4150,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[1994,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It is commonly believed that in short\u2010term tests hepatic cytochrome P\u2010450b inducers stimulate liver enlargement and mitogenesis in the absence of overt hepatotoxic effects. In this investigation male Wistar rats received naurimol (an organochlorine pesticide) in one, three and five oral doses of 31.5, 62.5 and 125 mg kg<jats:sup>\u2212<\/jats:sup>body wt. day<jats:sup>\u2212<\/jats:sup>, whereupon the effects on liver were determined. The early effects were dose\u2010dependent increases in <jats:italic>p<\/jats:italic>\u2010nitroanisole metabolism, hepatocyte proliferation (DNA synthesis and mitotic activity) and liver weight. Five administrations of the lowest does (31.5 mg kg<jats:sup>\u22121<\/jats:sup>body wt. day<jats:sup>\u22121<\/jats:sup>) did not change liver weight, despite increased <jats:italic>p<\/jats:italic>\u2010nitroanisole metabolism and hepatocyte proliferation. In contrast to <jats:italic>p<\/jats:italic>\u2010nitroanisole metabolism and hepatomegaly, proliferation was only transient and disappeared even when treatment continued. The increase in binuclear hepatocytes and signs of necrosis suggested that the hepatomitogenic effect of nuarimol reflected a regenerative response, which may simulate the proliferation caused by partial hepatectomy.<\/jats:p>","DOI":"10.1002\/jat.2550140504","type":"journal-article","created":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T04:55:38Z","timestamp":1160974538000},"page":"337-342","source":"Crossref","is-referenced-by-count":11,"title":["Early hepatic changes induced by nuarimol in rats"],"prefix":"10.1002","volume":"14","author":[{"given":"Grazyna","family":"Kostka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danuta","family":"Palut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Kope\u0107\u2010Szl\u0229zak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1218(83)90059-9"},{"issue":"4","key":"e_1_2_1_3_2","first-page":"325","article-title":"The influence of DDT analogues (nuarimol and fenarimol) on the micronuclei occurrence in the mice bone marrow and spleen erythrocytes","volume":"3","author":"Tyrkiel E.","year":"1992","journal-title":"Rocz. Panstw. Zakl. Hig."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(68)90153-1"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/11.8.1413"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(85)90355-7"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/00498258409151402"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/10408447409079856"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jat.2550120411"},{"key":"e_1_2_1_10_2","first-page":"129","volume-title":"Differential Toxicities of Insecticides and Halogenated Aromatics","author":"Khan M. A. Q.","year":"1983"},{"key":"e_1_2_1_11_2","first-page":"31","article-title":"Short\u2010term effect of buthylated hydroxytoluene in the Wistar rat liver, urinary bladder and thyroid gland","volume":"46","author":"Briggs D.","year":"1989","journal-title":"Cancer Res."},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00290879"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0022-3565(25)26886-0","article-title":"An adaptively stimulated O\u2010demethylating system in rat liver microsomes and its kinetic properties","volume":"146","author":"Netter J. K.","year":"1964","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1110(84)90002-2"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(91)90062-S"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/8.1.67"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/10915818909019550"},{"key":"e_1_2_1_19_2","first-page":"11","volume-title":"Mechanisms of Hepatocyte Injury and Death","author":"Desmet V. J.","year":"1984"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00296976"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01055383"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1159\/000217558"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.6.9.1612294"},{"key":"e_1_2_1_24_2","first-page":"91","volume-title":"Non\u2010genotoxic Mechanisms in Carcinogenesis","author":"Schulte\u2010Hermann R.","year":"1987"},{"key":"e_1_2_1_25_2","first-page":"213","article-title":"Early indicators of non\u2010genotoxic carcinogenesis. Overview. Proceedings of the Joint ECETOC\/IPSC Workshop, Brussels, June 1990","volume":"248","author":"Scientific and Organizing Committee","year":"1991","journal-title":"Mutat. Res."}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjat.2550140504","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.2550140504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T13:48:53Z","timestamp":1760536133000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.2550140504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,9]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1994,9]]}},"alternative-id":["10.1002\/jat.2550140504"],"URL":"https:\/\/doi.org\/10.1002\/jat.2550140504","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"type":"print","value":"0260-437X"},{"type":"electronic","value":"1099-1263"}],"subject":[],"published":{"date-parts":[[1994,9]]}}}