{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T05:54:28Z","timestamp":1762408468378,"version":"build-2065373602"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":3908,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[1995,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Frog Embryo Teratogenesis Assay\u2014<jats:italic>Xenopus<\/jats:italic> (FETAX) testing of a series of diverse hazardous waste\u2010site soil samples was performed to evaluate the efficacy of FETAX as a rapid developmental toxicity screening tool for environmental hazard assessment. Soil samples were collected from six different hazardous waste sites, three from eastern and three from western Washington State. The type of waste site samples studied, based on the contaminants identified, included: heavy metals (2), polymnuclear aromatic hydrocarbons, petroleum products (2) and organochlorine pesticides. Three to five samples from each site representing baseline and increasing levels of contamination were collected. Aqueous extracts of the soil samples were prepared and used for FETAX studies. Samples collected from the polynuclear aromatic hydrocarbon\u2010 and petroleum product\u2010contaminated sites induced greater levels of embryolethal effects, although embryonic malformation was also observed. The metal\u2010contaminated sites induced greater levels of embryonic malformation, but induced less embryolethality than the other samples evaluated. The organochlorine pesticide\u2010contaminated site samples caused significant levels of embryonic deformities but failed to induce embryolethal effects. Results from these studies suggested that FETAX was sensitive enough to detect low levels of developmental toxicants but robust enough to be suitable for aqueous soil extract testing. FETAX may be used as a component of a battery of tests designed to assess potential ecological hazard.<\/jats:p>","DOI":"10.1002\/jat.2550150308","type":"journal-article","created":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T05:36:18Z","timestamp":1160976978000},"page":"183-191","source":"Crossref","is-referenced-by-count":17,"title":["Ecological hazard assessment of aqueous soil extracts using fetax"],"prefix":"10.1002","volume":"15","author":[{"given":"Douglas J.","family":"Fort","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enos L.","family":"Stover","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale","family":"Norton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"105","article-title":"Teratogenicity testing in vitro: status of validation studies","volume":"11","author":"Brown N. A.","year":"1987","journal-title":"Arch. Toxicol. Suppl."},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1520-6866(1990)2:3\/4<221::AID-TCM1770020304>3.0.CO;2-7"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1897\/1552-8618(1988)7[27:EOTDTO]2.0.CO;2"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-3611-2_27"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jat.2550050405"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00027826"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jat.2550070403"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/tcm.1770080502"},{"volume-title":"New Standard Guide for Conducting the Frog Embryo Teratogenesis Assay\u2014Xenopus (FETAX)","year":"1991","author":"Bantle J. A.","key":"e_1_2_1_10_2"},{"volume-title":"Normal Tables of Xenopus laevis (Daudin)","year":"1975","author":"Nieuwkoop P. D.","key":"e_1_2_1_11_2"},{"volume-title":"Atlas of Abnormalities: a Guide for the Performance of FETAX","year":"1991","author":"Bantle J. A.","key":"e_1_2_1_12_2"},{"volume-title":"Protocol for Bioassessment of Hazardous Waste Sites","year":"1983","author":"Porcella D. B.","key":"e_1_2_1_13_2"},{"key":"e_1_2_1_14_2","unstructured":"D. J.Fort E. L.StoverandJ. A.Bantle Uses of FETAX in Ecological Hazard Assessment Environmental Toxicology and Risk Assessment: Transboundary Issues in Pollution\u2014 Air Surface and Groundwater: Fourth Volume ASTM STP 1212 ed. byT. W.LaPoint E. E.LittleandF. T.Price.American Society for Testing and Materials Philadelphia PA(1993)."},{"key":"e_1_2_1_15_2","unstructured":"D.NortonandM.Stinson Soil bioassay pilot study\u2014evaluation of screening level bioassays for use in soil toxicity assessments at hazardous waste sites under the model toxics control act. Washington State Department of Ecology Report (1993)."}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjat.2550150308","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.2550150308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T09:47:18Z","timestamp":1760521638000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.2550150308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,5]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,5]]}},"alternative-id":["10.1002\/jat.2550150308"],"URL":"https:\/\/doi.org\/10.1002\/jat.2550150308","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"type":"print","value":"0260-437X"},{"type":"electronic","value":"1099-1263"}],"subject":[],"published":{"date-parts":[[1995,5]]}}}