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Animals received either 40 or 80 mg kg<jats:sup>\u22121<\/jats:sup> ifosfamide intraperitoneally daily for 3 days every 3 weeks for a total of four treatment courses. Ifosfamide\u2010treated rats had significantly lower body weight and hematocrit than sterile water\u2010treated control rats. Animals receiving 40 mg kg<jats:sup>\u22121<\/jats:sup> ifosfamide developed isolated phosphaturia after their fourth and final treatment course. Rats receiving 80 mg kg<jats:sup>\u22121<\/jats:sup> ifosfamide had low\u2010grade glucosuria, phosphaturia and proteinuria throughout the study. Urine flow rate, creatinine clearance, urinary sodium and potassium excretion and kidney glutathione and malondialdehyde content were not affected by ifosfamide at either dose. These findings indicate that ifosfamide produces abnormalities in rat renal function resembling subclinical Fanconi syndrome.<\/jats:p>","DOI":"10.1002\/jat.2550150510","type":"journal-article","created":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T13:52:59Z","timestamp":1161093179000},"page":"399-402","source":"Crossref","is-referenced-by-count":10,"title":["Nephrotoxicity of ifosfamide in rats"],"prefix":"10.1002","volume":"15","author":[{"given":"James E.","family":"Springate","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith B.","family":"van Liew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.1.173"},{"key":"e_1_2_1_3_2","first-page":"311","article-title":"Renal toxicity in patients treated with ifosfamide on intergroup rhabdomyosarcoma study","volume":"3","author":"Foreman J.","year":"1992","journal-title":"J. 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