{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:56:39Z","timestamp":1760576199548,"version":"build-2065373602"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T00:00:00Z","timestamp":1331164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Fever has been reported as the most common adverse event after vaccination in infants and children. For this reason it is important that, prior to clinical testing of a new vaccine, change in body temperature following vaccination is tested carefully in nonclinical animal studies. Since both the timing and the height of the temperature peak after vaccination may differ from vaccine to vaccine, it is important that the time point for body temperature measurement should be chosen on a case\u2010by\u2010case basis with sufficient knowledge of the specific vaccine. In order to determine the best time point for rectal body temperature measurement after vaccination with a new vaccine candidate against <jats:italic>N<\/jats:italic>. <jats:italic>meningitidis<\/jats:italic> serogroup B, to be applied in a formal Good Laboratory Practice (GLP) toxicology study, miniature temperature data loggers were implanted into the peritoneal cavity of rabbits. The continuous body temperature monitoring appeared to give a complete picture of the entire body temperature kinetics after vaccination. The body temperature peaked at 4\u2009h after vaccination, and this time point was subsequently applied in the toxicology study. Measured body temperature values at the selected time point of 4\u2009h after vaccination were comparable in the continuous temperature setting and in the formal toxicology study, i.e. rectal temperature measurement at one time point. In the present study implanted temperature loggers were successfully used to define an adequate time point to be applied in determining rectal body temperature in a formal GLP toxicology study with a new vaccine candidate. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.2720","type":"journal-article","created":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T09:45:02Z","timestamp":1331199902000},"page":"521-526","source":"Crossref","is-referenced-by-count":10,"title":["Nonclinical vaccine safety evaluation: advantages of continuous temperature monitoring using abdominally implanted data loggers"],"prefix":"10.1002","volume":"33","author":[{"given":"Patricia","family":"Kaaijk","sequence":"first","affiliation":[{"name":"Unit Vaccinology Centre for Infectious Disease Control, National Institute for Public Health and the Environment  Bilthoven the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arno A. 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