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Male and female Swiss mice 7\u20138\u2009weeks old (<jats:italic>N<\/jats:italic>\u2009=\u200948) were treated by gavage with 1\u2009g\u2009kg<jats:sup>\u22121<\/jats:sup> body weight and 0.5\u2009g\u2009kg<jats:sup>\u22121<\/jats:sup> body weight of watercress juice during 15 consecutive days. Genotoxicity and its possible protective effect were tested by the comet assay in peripheral blood cells and the micronucleus test in bone marrow. In addition, biopsies of the bladder, epididymis and testicles of mice were performed to extend the experimental design. Watercress juice <jats:italic>per se<\/jats:italic> did not induce genetic damage according to the comet assay and micronucleus study, exhibiting a protective activity against CP (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 and <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, respectively). The comparative analysis of bladder histological changes obtained in the watercress plus CP group against those treated with CP alone suggests a probable protective effect. Further studies are needed in order to establish the protective role of watercress juice against DNA damage. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.2746","type":"journal-article","created":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T13:22:40Z","timestamp":1333545760000},"page":"880-885","source":"Crossref","is-referenced-by-count":11,"title":["<i>In vivo<\/i> antigenotoxic activity of watercress juice <i>(Nasturtium officinale)<\/i> against induced DNA damage"],"prefix":"10.1002","volume":"33","author":[{"given":"Natalia A.","family":"Casanova","sequence":"first","affiliation":[{"name":"Citogen\u00e9tica Humana y Gen\u00e9tica Toxicol\u00f3gica, Instituto de Fisiopatolog\u00eda y Bioqu\u00edmica Cl\u00ednica, Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Farmacia y Bioqu\u00edmica Universidad de Buenos Aires  Jun\u00edn 956 1113 CABA Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia I.","family":"Ariagno","sequence":"additional","affiliation":[{"name":"Laboratorio de Fertilidad Masculina, Instituto de Fisiopatolog\u00eda y Bioqu\u00edmica Cl\u00ednica, Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Farmacia y Bioqu\u00edmica Universidad de Buenos Aires  Jun\u00edn 956 1113 CABA Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela M.","family":"L\u00f3pez Nigro","sequence":"additional","affiliation":[{"name":"Citogen\u00e9tica Humana y Gen\u00e9tica Toxicol\u00f3gica, Instituto de Fisiopatolog\u00eda y Bioqu\u00edmica Cl\u00ednica, Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Farmacia y Bioqu\u00edmica Universidad de Buenos Aires  Jun\u00edn 956 1113 CABA Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela R.","family":"Mendeluk","sequence":"additional","affiliation":[{"name":"Laboratorio de Fertilidad Masculina, Instituto de Fisiopatolog\u00eda y Bioqu\u00edmica Cl\u00ednica, Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Farmacia y Bioqu\u00edmica Universidad de Buenos Aires  Jun\u00edn 956 1113 CABA Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda de los A.","family":"Gette","sequence":"additional","affiliation":[{"name":"Universidad Nacional de San Luis  Av. 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