{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:46:37Z","timestamp":1760575597450,"version":"build-2065373602"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,5,25]],"date-time":"2012-05-25T00:00:00Z","timestamp":1337904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>In a previous study, the predictive capacity of a modified local lymph node assay (LLNA) based on cell counts, the LNCC, was demonstrated to be closely similar to that of the original assay. In addition, a range of substances, including some technical\/commercial materials and a range of agrochemical formulations (<jats:italic>n<\/jats:italic>\u2009=\u2009180) have also been assessed in both methods in parallel. The results in the LNCC and LLNA were generally consistent, with 86% yielding an identical classification outcome. Discordant results were associated with borderline data and were evenly distributed between the two methods. Potency information derived from each method also demonstrated good consistency (<jats:italic>n<\/jats:italic>\u2009=\u2009101), with 93% of predictions being close. Skin irritation was observed only infrequently and was most commonly associated with positive results; it was not associated with the discordant results. Where different vehicles were used with the same test material, the effect on sensitizing activity was modest, consistent with historical data. Analysis of positive control data indicated that the LNCC and LLNA displayed similar levels of biological variation. When taken in combination with the previously published results on LLNA Performance Standard chemicals, it is concluded that the LNCC provides a viable non\u2010radioactive alternative to the LLNA for the assessment of substances, including potency predictions, as well as for the evaluation of preparations. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.2754","type":"journal-article","created":{"date-parts":[[2012,5,25]],"date-time":"2012-05-25T07:24:41Z","timestamp":1337930681000},"page":"597-607","source":"Crossref","is-referenced-by-count":6,"title":["Further experience with the local lymph node assay using standard radioactive and nonradioactive cell count measurements"],"prefix":"10.1002","volume":"32","author":[{"given":"Susanne N.","family":"Kolle","sequence":"first","affiliation":[{"name":"BASF SE Experimental Toxicology and Ecology  Ludwigshafen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Basketter","sequence":"additional","affiliation":[{"name":"DABMEB Consultancy Ltd  Sharnbrook UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnhild","family":"Schrage","sequence":"additional","affiliation":[{"name":"BASF SE Product Safety  Ludwigshafen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin O.","family":"Gamer","sequence":"additional","affiliation":[{"name":"BASF SE Experimental Toxicology and Ecology  Ludwigshafen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bennard","family":"van Ravenzwaay","sequence":"additional","affiliation":[{"name":"BASF SE Experimental Toxicology and Ecology  Ludwigshafen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Landsiedel","sequence":"additional","affiliation":[{"name":"BASF SE Experimental Toxicology and Ecology  Ludwigshafen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-011-0693-2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2011.05.007"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00490.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2009.06.005"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01141.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-03827-3_13"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2011.07.004"},{"key":"e_1_2_6_9_1","article-title":"Experience with local lymph node assay performance standards using standard radioactivity and non\u2010radioactive cell count measurements","author":"Basketter DA","year":"2011","journal-title":"J. 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