{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T06:24:35Z","timestamp":1774679075978,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,5,19]],"date-time":"2012-05-19T00:00:00Z","timestamp":1337385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The aims of the present study were to determine cytochrome P450 enzyme activity in six strains of experimental rodents (<jats:italic>n<\/jats:italic>\u2009=\u20095\/sex\/species): ICR, C57BL\/6 and DBA\/2 mice; Sprague Dawley and Wistar rats; and Dunkin Hartley guinea pigs. After animals were treated with the typical inducers \u03b2\u2010naphthoflavone (BNF), dexamethasone (DEX) and phenobarbital (PB), the levels of <jats:italic>O<\/jats:italic>\u2010dealkylation of ethoxyresorufin (EROD), methoxyresorufin (MROD), pentoxyresorufin (PROD) and benzyloxyresorufin (BROD) activity were determined using responsive catalytic reactions to study CYP1A1, CYP1A2 and CYP2B, respectively. A maximal induction of EROD and MROD was found in BNF\u2010treated animals from all strains (2.4\u2010 to 15.1\u2010fold) except DBA\/2 (0.9\u2010 to 1.8\u2010fold). C57BL\/6 mice had the strongest BNF\u2010induced EROD (15.1\u2010fold) and MROD (8.3\u2010fold) activities. No differences in BNF\u2010induced EROD and MROD activities were observed between males and females. However, the EROD activity of Wistar rats and the MROD activity of Sprague Dawley rats were higher in males than females. DEX induced PROD activity only in mice (1.3\u2010 to 7.1\u2010fold), but not in rats and guinea pigs (0.2\u2010 to 1.1\u2010fold). However, induction of BROD activity was found in DEX\u2010treated mice and rats (1.5 to 12.5\u2010fold), but not in guinea pigs (0.3 to 0.4\u2010fold). PB caused a significant elevation of PROD (1.7\u2010 to 10.4\u2010fold) and BROD (31\u2010 to 13.2\u2010fold) activities in all the animals. PB\u2010induced BROD activity was higher in females than males in Sprague Dawley rats. These observations strongly suggest that the choice of experimental animal strain, species and inducer is of critical importance for studies of drug metabolism and interaction. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.2756","type":"journal-article","created":{"date-parts":[[2012,5,20]],"date-time":"2012-05-20T09:00:42Z","timestamp":1337504442000},"page":"1002-1007","source":"Crossref","is-referenced-by-count":6,"title":["Different profiles of hepatic alkoxyresorufin <i>O<\/i>\u2010dealkylase activities in small rodents"],"prefix":"10.1002","volume":"32","author":[{"given":"Waranya","family":"Chatuphonprasert","sequence":"first","affiliation":[{"name":"Research Group for Pharmaceutical Activities of Natural Products using Pharmaceutical Biotechnology (PANPB), Faculty of Pharmaceutical Sciences National Research University\u2010Khon Kaen University  Khon Kaen 40002 Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Papimon","family":"Rermraksakul","sequence":"additional","affiliation":[{"name":"Research Group for Pharmaceutical Activities of Natural Products using Pharmaceutical Biotechnology (PANPB), Faculty of Pharmaceutical Sciences National Research University\u2010Khon Kaen University  Khon Kaen 40002 Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Latiporn","family":"Udomsuk","sequence":"additional","affiliation":[{"name":"Research Group for Pharmaceutical Activities of Natural Products using Pharmaceutical Biotechnology (PANPB), Faculty of Pharmaceutical Sciences National Research University\u2010Khon Kaen University  Khon Kaen 40002 Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thinnakorn","family":"Lao\u2010ong","sequence":"additional","affiliation":[{"name":"Research Group for Pharmaceutical Activities of Natural Products using Pharmaceutical Biotechnology (PANPB), Faculty of Pharmaceutical Sciences National Research University\u2010Khon Kaen University  Khon Kaen 40002 Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanokwan","family":"Jarukamjorn","sequence":"additional","affiliation":[{"name":"Research Group for Pharmaceutical Activities of Natural Products using Pharmaceutical Biotechnology (PANPB), Faculty of Pharmaceutical Sciences National Research University\u2010Khon Kaen University  Khon Kaen 40002 Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(85)90355-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(94)90363-8"},{"key":"e_1_2_7_4_1","first-page":"4875","article-title":"Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes memorial lecture","volume":"42","author":"Conney AH","year":"1982","journal-title":"Cancer Res."},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0031-6997(25)00021-3","article-title":"The molecular biology of cytochrome P450s","volume":"40","author":"Gonzalez FJ","year":"1989","journal-title":"Pharmacol. Rev."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.6.2.1537465"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx00022a001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"10182","DOI":"10.1016\/S0021-9258(17)44622-9","article-title":"Cloning of DNA complementary to cytochrome P\u2010450 induced by pregnenolone\u201016 alpha\u2010carbonitrile: Characterization of its mRNA, gene, and induction response","volume":"258","author":"Hardwick JP","year":"1983","journal-title":"J. Biol. Chem."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3300889"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1042\/bj3470321","article-title":"Regulation of cytochrome P450 (CYP) genes by nuclear receptors","volume":"15","author":"Honkakoski P","year":"2000","journal-title":"Biochem. J."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2007.07.008"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1999.1342"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(01)00656-6"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.9.6318"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.45.120403.100010"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2944(84)90007-3"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(86)90177-1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1037886100"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-711X(89)90182-1"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.1991.10.1"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(99)00310-X"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1993.tb02867.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1995.1294"},{"key":"e_1_2_7_24_1","first-page":"5863","article-title":"Proline\u2010dependent expression of aryl hydrocarbon hydroxylase in C57BL\/6 mouse hepatocytes in primary culture","volume":"49","author":"Nemoto N","year":"1989","journal-title":"Cancer Res."},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1086\/499369"},{"key":"e_1_2_7_26_1","first-page":"2","volume-title":"Pet Rodent to Research Materials (1900\u201321)","author":"Rader KA","year":"2004"},{"key":"e_1_2_7_27_1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0026-895X(25)09289-2","article-title":"Piperonyl butoxide and acenaphthylene induce cytochrome P450 1A2 and 1B1 mRNA in aromatic hydrocarbon\u2010responsive receptor knock\u2010out mouse liver","volume":"50","author":"Ryu DY","year":"1996","journal-title":"Mol. Pharmacol."},{"key":"e_1_2_7_28_1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0090-9556(24)14914-8","article-title":"Induction of CYP1A2 by phenobarbital in the livers of aryl hydrocarbon\u2010responsive and \u2010nonresponsive mice","volume":"27","author":"Sakuma T","year":"1999","journal-title":"Drug Metab. Dispos."},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(94)00916-G"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7240.987"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R100033200"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(97)00476-0"}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjat.2756","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.2756","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T10:06:58Z","timestamp":1760522818000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.2756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,19]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1002\/jat.2756"],"URL":"https:\/\/doi.org\/10.1002\/jat.2756","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"value":"0260-437X","type":"print"},{"value":"1099-1263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,19]]}}}