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Therefore, for the successful application of QDs in bioscience, it is essential to understand their biological fate and toxicity. We investigated toxicological effects and tissue distribution of mercaptopropionic acid\u2010conjugated cadmium selenide\/cadmium sulfide (CdSe\/CdS\u2010MPA) QDs after repeated intraperitoneal injection into BALB\/c mice. The mice were injected every 3\u2009days with various doses of QDs (0, 5, 10 and 25\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>). The subsequent effects of QDs on plasma levels of various biomarkers were evaluated at different time points (at 0, 1, 4, 7, 10, 13 and 15\u2009days). Various tissue samples (spleen, liver, lung, kidneys, brain, heart and thymus) were collected for toxicity analysis, distribution testing, histopathological examination and inflammation assessment. No abnormal clinical signs or behaviors were recorded but the body weight of mice treated with 25\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup> QDs was significantly decreased from day 7 compared with control mice. QDs were observed in the liver, spleen, lung and kidneys, but not in brain or heart. Significantly higher levels of lactate dehydrogenase and nicotinamide adenine dinucleotide phosphate oxidase were found in the plasma, liver and spleen. Histopathological examination did not show any tissue toxicity but the levels of interleukin\u20106, a pro\u2010inflammatory marker, were increased in the plasma, liver and spleen. All of these findings provide insight into the observed toxicological effect levels and tissue\u2010specific distribution of CdSe\/CdS\u2010MPA QDs. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.2775","type":"journal-article","created":{"date-parts":[[2012,6,25]],"date-time":"2012-06-25T11:29:42Z","timestamp":1340623782000},"page":"940-950","source":"Crossref","is-referenced-by-count":56,"title":["Acute toxicity and tissue distribution of CdSe\/CdS\u2010MPA quantum dots after repeated intraperitoneal injection to mice"],"prefix":"10.1002","volume":"33","author":[{"given":"Md. 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