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In the present study, the Cd effect on ovary \u03b4\u2010aminolevulinate dehydratase (\u03b4\u2010ALA\u2010D) activity was investigated <jats:italic>in vitro<\/jats:italic> and <jats:italic>ex vivo<\/jats:italic>. We observed that low concentrations of Cd inhibited cow ovary \u03b4\u2010ALA\u2010D activity <jats:italic>in vitro<\/jats:italic> and the IC<jats:sub>50<\/jats:sub> value obtained was 19.17\u2009\u03bcM. Furthermore, the protective effect of a novel organic selenium compound (seleno\u2010furanoside) in restoring enzyme activity was evaluated. Seleno\u2010furanoside (10, 50, 100, 200, 400 and 1000\u2009\u03bcM) did not reverse the Cd toxicity in bovine ovarian tissue <jats:italic>in vitro<\/jats:italic>. According to the <jats:italic>in vitro<\/jats:italic> reults, acute Cd exposure (2.5 and 5\u2009mg\u2009kg<jats:sup>\u20131<\/jats:sup>) caused a significant inhibition in ovary \u03b4\u2010ALA\u2010D activity in mice (around 27% and 34%, respectively). Therapy with seleno\u2010furanoside (100 \u00b5mol kg<jats:sup>\u20131<\/jats:sup>) was able to restore enzyme activity. Thus, we demonstrated for the first time that \u03b4\u2010ALA\u2010D activity from ovary is inhibited by Cd both <jats:italic>in vitro<\/jats:italic> and <jats:italic>ex vivo<\/jats:italic>. Additionally, seleno\u2010furanoside therapy was effective in restoring ovarian enzyme activity inhibited by Cd exposure in mice, but it did not reverse the <jats:italic>in vitro<\/jats:italic> metal effect. This study detected a new toxicity marker of Cd toxicity on ovarian tissue as well as the beneficial effect of a new compound to manage the metal effect after acute exposure. 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