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In this study, cirrhosis was induced by chronic TAA administration and the effects of co\u2010administration of conventional caffeinated coffee or decaffeinated coffee (CC, DC, respectively) for 8\u2009weeks were evaluated. TAA administration elevated serum alkaline phosphatase (AP), \u03b3\u2010glutamyl transpeptidase (\u03b3\u2010GTP) and alanine aminotransferase (ALAT), liver lipid peroxidation, collagen content, depleted liver glycogen and glutathione peroxidase (GPx) activity. Additionally increased levels of a number of proteins were detected including transforming growth factor\u2010beta (TGF\u2010\u03b2), connective tissue growth factor (CTGF) and alpha\u2010smooth muscle actin (\u03b1\u2010SMA), and matrix metalloproteinase (MMP)\u20102, 9 and 13. Coffee suppressed most of the changes produced by TAA. Histopathological analysis was in agreement with biochemical and molecular findings. These results indicate that coffee attenuates experimental cirrhosis; the action mechanisms are probably associated with its antioxidant properties and mainly by its ability to block the elevation of the profibrogenic cytokine TGF\u2010\u03b2 and its downstream effector CTGF. Various components of coffee that have been related to such a favorable effect include caffeine, coffee oils kahweol, cafestol and antioxidant substances; however, no definite evidence for the role of these components has been established. These results support earlier findings suggesting a beneficial effect of coffee on the liver. However, more basic clinical studies must be performed to confirm this hypothesis. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.2788","type":"journal-article","created":{"date-parts":[[2012,8,17]],"date-time":"2012-08-17T06:03:15Z","timestamp":1345183395000},"page":"970-979","source":"Crossref","is-referenced-by-count":73,"title":["Coffee attenuates fibrosis by decreasing the expression of TGF\u2010\u03b2 and CTGF in a murine model of liver damage"],"prefix":"10.1002","volume":"33","author":[{"given":"Jonathan","family":"Arauz","sequence":"first","affiliation":[{"name":"Departamento de Farmacolog\u00eda Cinvestav\u2010IPN  Apdo Postal 14\u2010740 M\u00e9xico 07000 D. F. M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Galicia\u2010","family":"Moreno","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda Cinvestav\u2010IPN  Apdo Postal 14\u2010740 M\u00e9xico 07000 D. F. 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