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Different studies confirm the multiple biological roles of and possible protective effects of ghrelin. Multiple <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> studies support the powerful protective action of ghrelin against heart, gastric and liver injury. Moreover, ghrelin has been reported to be beneficial in renal tissue injury and excretory function after ischemia\u2013reperfusion and to exert neuroprotective effects in cerebral ischemic regions. The aim of this review is to summarize and evaluate all the currently available <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> studies regarding the effects of ghrelin on tissue injury induced in different organs and tissues. 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