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Here, we investigated the effect of PPAR\u2010\u03b3 agonist pioglitazone against acute renal injury on a cisplatin model in mice. Nephrotoxicity was induced by a single intraperitoneal (i.p.) injection of cisplatin (10\u2009mg\u2009kg<jats:sup>\u20131<\/jats:sup>). Pioglitazone was administered for six consecutive days in doses of 15 or 30\u2009mg\u2009kg<jats:sup>\u20131<\/jats:sup>\u2009day<jats:sup>\u20131<\/jats:sup>, <jats:italic>per os<\/jats:italic> (p.o.), starting 3\u2009days before cisplatin injection. Cisplatin treatment to mice induced a marked renal failure, characterized by a significant increase in serum urea and creatinine levels and alterations in renal tissue architecture. Cisplatin exposure induced oxidative stress as indicated by decreased levels of non\u2010enzymatic antioxidant defenses [glutathione (GSH) and ascorbic acid levels] and components of the enzymatic antioxidant defenses [superoxide dismutase (SOD), catalase (CAT) glutathione peroxidase (GPx), glutathione reductase (GR) and and glutathione S\u2010transferase(GST) activities)] in renal tissue. Administration of pioglitazone markedly protected against the increase in urea and creatinine levels and histological alterations in kidney induced by cisplatin treatment. Pioglitazone administration ameliorated GSH and ascorbic acid levels decreased by cisplatin exposure in mice. Pioglitazone protected against the inhibition of CAT, SOD, GPx, GR and GST activities induced by cisplatin in the kidneys of mice. These results indicated that pioglitazone has a protective effect against cisplatin\u2010induced renal damage in mice. The protection is mediated by preventing the decline of antioxidant status. The results have implications in use of PPAR\u2010\u03b3 agonists in human application for protecting against drugs\u2010induced nephrotoxicity. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.2818","type":"journal-article","created":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T23:33:22Z","timestamp":1383089602000},"page":"25-32","source":"Crossref","is-referenced-by-count":39,"title":["The peroxisome proliferator\u2010activated receptor\u2010\u03b3 agonist pioglitazone protects against cisplatin\u2010induced renal damage in mice"],"prefix":"10.1002","volume":"34","author":[{"given":"Cristiano R.","family":"Jesse","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Avalia\u00e7\u00f5es Farmacol\u00f3gicas e Toxicol\u00f3gicas Aplicadas \u00e0s Mol\u00e9culas Bioativas \u2013 <i>LaftamBio<\/i> Pampa Universidade Federal do Pampa  CEP 97650\u2010000 Itaqui RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiani F.","family":"Bortolatto","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de S\u00edntese, Reatividade e Avalia\u00e7\u00e3o Farmacol\u00f3gica e Toxicol\u00f3gica de Organocalcog\u00eanios, Departamento de Qu\u00edmica, Centro de Ci\u00eancias Naturais e Exatas Universidade Federal de Santa Maria  CEP 97105\u2010900 Santa Maria RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethel A.","family":"Wilhelm","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de S\u00edntese, Reatividade e Avalia\u00e7\u00e3o Farmacol\u00f3gica e Toxicol\u00f3gica de Organocalcog\u00eanios, Departamento de Qu\u00edmica, Centro de Ci\u00eancias Naturais e Exatas Universidade Federal de Santa Maria  CEP 97105\u2010900 Santa Maria RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvane Souza","family":"Roman","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias da Sa\u00fade Universidade Regional Integrada do Alto Uruguai e das Miss\u00f5es, Campus de Erechim, RS  CEP 99700\u2010000 Erechim Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Prigol","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Avalia\u00e7\u00f5es Farmacol\u00f3gicas e Toxicol\u00f3gicas Aplicadas \u00e0s Mol\u00e9culas Bioativas \u2013 <i>LaftamBio<\/i> Pampa Universidade Federal do Pampa  CEP 97650\u2010000 Itaqui RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina W.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de S\u00edntese, Reatividade e Avalia\u00e7\u00e3o Farmacol\u00f3gica e Toxicol\u00f3gica de Organocalcog\u00eanios, Departamento de Qu\u00edmica, Centro de Ci\u00eancias Naturais e Exatas Universidade Federal de Santa Maria  CEP 97105\u2010900 Santa Maria RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2006.06.011"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2006.01.013"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0270-9295(03)00089-5"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2005.04.016"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005090983"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.761_2.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1449"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(85)13062-4"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1385\/BTER:83:3:251"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2004.03.004"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2006.12.004"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114656"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000103629.01745.59"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2005.11.006"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2007.10.026"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000420651"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200059004-00002"},{"key":"e_1_2_5_21_1","first-page":"7130","article-title":"Glutathione S\u2010transferase. 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