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Four alternative tests have so far been submitted to ECVAM prevalidation: (i) MUSST and (ii) h\u2010Clat assess surface markers on dendritic cell lines, (iii) the direct peptide reactivity assay (DPRA) measures reactivity with model peptides and (iv) the KeratinoSens<jats:sup>TM<\/jats:sup> assay which is based on detection of Nrf2\u2010induced luciferase. It is anticipated that only an integrated testing strategy (ITS) based on a battery of tests might give a full replacement providing also a sensitization potency assessment, but this concept should be tested with a data\u2010driven analysis. Here we report a database on 145 chemicals reporting the quantitative endpoints measured in a U937\u2010 test, the DPRA and KeratinoSens<jats:sup>TM<\/jats:sup> . It can serve to develop data\u2010driven ITS approaches as we show in a parallel paper and provides a view as to the current ability to predict with <jats:italic>in vitro<\/jats:italic> tests as we are entering 2013. It may also serve as reference database when benchmarking new molecules with <jats:italic>in vitro<\/jats:italic> based read\u2010across and find use as a reference database when evaluating new tests. The tests and combinations thereof were evaluated for predictivity, and overall a similar predictivity was found as before on three\u2010fold smaller datasets. Analysis of the dose\u2013response parameters of the individual tests indicates a correlation to sensitization potency. Detailed analysis of chemicals false\u2010negative and false\u2010positive in two tests helped to define limitations in the tests but also in the database derived from animal studies. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.2868","type":"journal-article","created":{"date-parts":[[2013,4,10]],"date-time":"2013-04-10T00:18:32Z","timestamp":1365553112000},"page":"1337-1352","source":"Crossref","is-referenced-by-count":319,"title":["A dataset on 145 chemicals tested in alternative assays for skin sensitization undergoing prevalidation"],"prefix":"10.1002","volume":"33","author":[{"given":"Andreas","family":"Natsch","sequence":"first","affiliation":[{"name":"Givaudan Schweiz AG  Ueberlandstrasse 138 CH\u20108600 D\u00fcbendorf Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy A.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Procter &amp; Gamble Company  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Foertsch","sequence":"additional","affiliation":[{"name":"Procter &amp; Gamble Company  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Emter","sequence":"additional","affiliation":[{"name":"Givaudan Schweiz AG  Ueberlandstrasse 138 CH\u20108600 D\u00fcbendorf Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Jaworska","sequence":"additional","affiliation":[{"name":"Procter &amp; Gamble NV  100 Temselaan 1853 Strombeek \u2010 Bever Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Gerberick","sequence":"additional","affiliation":[{"name":"Procter &amp; Gamble Company  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Kern","sequence":"additional","affiliation":[{"name":"Procter &amp; Gamble NV  100 Temselaan 1853 Strombeek \u2010 Bever Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476910600978038"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2007.10.008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2005.10.012"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2011.05.007"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(01)00130-2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1443"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2006.00930.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1995.tb00443.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2012.05.013"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/026119290903700313"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx200196s"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2010.03.009"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1177\/026119290803600210","article-title":"Chemical reactivity measurement and the predictive identification of skin sensitisers","volume":"36","author":"Gerberick F","year":"2008","journal-title":"Altern. 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