{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:39:57Z","timestamp":1787067597852,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T00:00:00Z","timestamp":1366934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The prognosis for fulminant hepatic failure (FHF) still remains extremely poor with a high mortality and, therefore, better treatments are urgently needed. Syringin, a main active substance isolated from\n                    <jats:italic>Eleutherococcus senticosus<\/jats:italic>\n                    , has been reported to exhibit immunomodulatory and anti\u2010inflammatory properties. In this study, we investigated the effects and underlying mechanisms of syringin on lipopolysaccharide (LPS) and D\u2010galactosamine (D\u2010GalN)\u2010induced FHF in mice. Mice were administered syringin (10, 30 and 100\u2009mg\u2009kg\n                    <jats:sup>\u20131<\/jats:sup>\n                    , respectively) intraperitoneally (i.p) 30\u2009min before LPS\/D\u2010GalN then mortality and liver injury were evaluated subsequently. We found that syringin dose\u2010dependently attenuated LPS\/D\u2010GalN\u2010induced FHF, as indicated by reduced mortality, inhibited aminotransferase and malondialdehyde (MDA) content, an increased glutathione (GSH) concentration and alleviated pathological liver injury. In addition, syringin inhibited LPS\/D\u2010GalN\u2010induced hepatic caspase\u20103 activation and hepatocellular apoptosis, myeloperoxidase (MPO) activity and intercellular adhesion molecule\u20101 (ICAM\u20101) expression, as well as hepatic tissues tumor necrosis factor\u2010alpha (TNF\u2010\u03b1) production and NF\u2010\u03baB activation in a dose\u2010dependent manner. These experimental data indicate that syringin might alleviate the FHF induced by LPS\/D\u2010GalN through inhibiting NF\u2010\u03baB activation to reduce TNF\u2010\u03b1 production. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/jat.2876","type":"journal-article","created":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T03:38:11Z","timestamp":1366947491000},"page":"265-271","source":"Crossref","is-referenced-by-count":47,"title":["Hepatoprotective effects of syringin on fulminant hepatic failure induced by D\u2010galactosamine and lipopolysaccharide in mice"],"prefix":"10.1002","volume":"34","author":[{"given":"Xia","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Anatamy Chongqing Medical University  Chongqing 400016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology Chongqing Medical University  Chongqing 400016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Laboratory of 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