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We evaluated the effects of edaravone, a neuroprotective agent, on neomycin\u2010induced ototoxicity in transgenic zebrafish. The 5\u2010day post fertilization (dpf) zebrafish larvae were exposed to 125\u2009\u03bcM neomycin and various concentrations of edaravone for 1\u2009h. Hair cell survival was calculated as average numbers of the hair cells in the control group, which was not exposed to neomycin. Ultrastructural changes were evaluated using a scanning electron microscope (SEM) and transmission electron microscope (TEM). Edaravone protected against neomycin\u2010induced hair cell loss in the neuromasts (1000\u2009\u03bcM: 11.6\u2009\u00b1\u20091.1 cells, neomycin only: 5.5\u2009\u00b1\u20090.5 cells; <jats:italic>n<\/jats:italic>\u2009=\u200910, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and decreased the TUNEL reaction for detecting apoptosis. In ultrastructural analysis, structures of mitochondria and hair cells within neuromasts were preserved in zebrafish exposed to 125\u2009\u03bcM neomycin and 1000\u2009\u03bcM edaravone for 1\u2009h. Edaravone protected against neomycin\u2010induced hair cell loss by preventing apoptosis. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.2964","type":"journal-article","created":{"date-parts":[[2013,12,3]],"date-time":"2013-12-03T07:12:43Z","timestamp":1386054763000},"page":"554-561","source":"Crossref","is-referenced-by-count":21,"title":["Protective role of edaravone against neomycin\u2010induced ototoxicity in zebrafish"],"prefix":"10.1002","volume":"34","author":[{"given":"June","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Korea University Ansan Hospital, Korea University College of Medicine  Ansan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiwon","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Korea University Ansan Hospital, Korea University College of Medicine  Ansan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung 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