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We showed previously that sibutramine, a norepinephrine\/serotonine reuptake inhibitor, reduced male rat fertility. As there are no studies evaluating the impact of bupropion treatment on spermatic parameters and male fertility, we evaluated the effects of bupropion treatment (15 and 30\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>, 30\u2009days) on sexual behavior, spermatic parameters and fertility of male Wistar rats and on the epididymal duct <jats:italic>in vitro<\/jats:italic> contractility. Bupropion 15\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup> increased the serum luteinizing hormone level and the epididymal duct contractility, but the sperm quality was not affected. At 30\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup> bupropion impaired sperm quality increasing the incidence of non\u2010progressive sperm. The male sexual behavior and fertility were not modified at both bupropion doses. These results, in rats, suggest the importance of studies evaluating the effects of bupropion on the human male sperm quality. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.3089","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T20:37:02Z","timestamp":1422909422000},"page":"1007-1016","source":"Crossref","is-referenced-by-count":23,"title":["Bupropion treatment increases epididymal contractility and impairs sperm quality with no effects on the epididymal sperm transit time of male rats"],"prefix":"10.1002","volume":"35","author":[{"given":"Marilia Martins","family":"Cavariani","sequence":"first","affiliation":[{"name":"Department of Morphology, Institute of Biosciences UNESP \u2013 Univ. 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