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Male and female Crl:CD(SD) rats (12 per sex per group) were exposed to 20\u2009kHz, 0.20 mT(root mean square, rms) or 60\u2009kHz, 0.10\u2009mT(rms) sinusoidal MFs for 22\u2009h\u2009day<jats:sup>\u22121<\/jats:sup> for 14\u2009days (acute) or 13\u2009weeks (subchronic). Experiments were duplicated for each frequency to ensure outcome reproducibility, and examinations were blinded for quality assurance. All rats survived without significant clinical signs until the end of experiments. Some changes in body weight between the MF\u2010exposed and control groups were observed over the course of exposure, although the directions of the changes were inconsistent and not statistically significant after subchronic exposure. There were significant differences between MF\u2010exposed and control groups in some organ weights and parameters in hematology and clinical chemistry, but these were minor in magnitude and not repeated in duplicate experiments. Histopathological findings reflecting toxicity were sporadic. Frequencies of other findings were similar to historic data in this rat strain, and findings had no specific relationship to changes in organ weight or parameters of hematology and clinical chemistry in each animal. The changes observed throughout this study were considered biologically isolated and were attributable to chance associations rather than to MF exposure. The results, in particular the histopathological evidence, indicate an absence of toxicity in IF MF\u2010exposed rats and do not support the hypothesis that IF MF exposure produces significant toxicity. Copyright \u00a9 2015. The Authors. <jats:italic>Journal of Applied Toxicology<\/jats:italic> Published by John Wiley &amp; Sons Ltd.<\/jats:p>","DOI":"10.1002\/jat.3161","type":"journal-article","created":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T01:33:11Z","timestamp":1431912791000},"page":"199-210","source":"Crossref","is-referenced-by-count":10,"title":["Acute and subchronic toxicity of 20\u2009\u2009kHz and 60\u2009\u2009kHz magnetic fields in rats"],"prefix":"10.1002","volume":"36","author":[{"given":"Izumi","family":"Nishimura","sequence":"first","affiliation":[{"name":"Environmental Science Research Laboratory Central Research Institute of Electric Power Industry  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Oshima","sequence":"additional","affiliation":[{"name":"Contract Testing Department Nippon Institute for Biological Science  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumoto","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Contract Testing Department Nippon Institute for Biological Science  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Mitani","sequence":"additional","affiliation":[{"name":"Environmental Science Research Laboratory Central Research Institute of Electric Power Industry  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Negishi","sequence":"additional","affiliation":[{"name":"Environmental Science Research Laboratory Central Research Institute of Electric Power Industry  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/019262390908371"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1049\/ip-epa:20000017"},{"key":"e_1_2_7_4_1","first-page":"2081","article-title":"Design and optimisation of magnetic structures for lumped inductive power transfer systems","author":"Budhia M","year":"2009","journal-title":"IEEE Energy Conv. 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