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However, little is known about the effects of Cd on the glomerular endothelium, which performs the filtration function and directly interacts with Cd in blood plasma. In this study, we cultured human renal glomerular endothelial cells (HRGECs) in the presence of serum with treatment of a short term (1\u2009h) and low concentration (1\u2009<jats:italic>\u03bc<\/jats:italic>m) of Cd, which mimics the pattern of glomerular endothelium exposure to Cd <jats:italic>in vivo<\/jats:italic>. We found that this short\u2010term, low\u2010dose Cd exposure does not induce cytotoxicity, but increases permeability in HRGECs monolayers and redistributes adherens junction proteins vascular endothelial\u2010cadherin and \u03b2\u2010catenin. Though short\u2010term, low\u2010dose Cd exposure activates all three major mitogen activated protein kinases, only the inhibitor of p38 mitogen activated protein kinase partially prevents Cd\u2010induced hyperpermeability in HRGECs. Our data indicate that the presence of Cd in blood circulation might directly disrupt the glomerular endothelial cell barrier and contribute to the development of clinical symptoms of glomerular diseases. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.3168","type":"journal-article","created":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T23:31:28Z","timestamp":1432596688000},"page":"257-265","source":"Crossref","is-referenced-by-count":39,"title":["Short\u2010term, low\u2010dose cadmium exposure induces hyperpermeability in human renal glomerular endothelial cells"],"prefix":"10.1002","volume":"36","author":[{"given":"Liqun","family":"Li","sequence":"first","affiliation":[{"name":"Laboratory of Microvascular Medicine, Medical Research Center, Shandong Provincial Qianfoshan Hospital Shandong University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengyun","family":"Dong","sequence":"additional","affiliation":[{"name":"Laboratory of Microvascular Medicine, Medical Research Center, Shandong Provincial Qianfoshan Hospital Shandong University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongmei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shandong Provincial Qianfoshan Hospital Shandong University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linna","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shandong Provincial Qianfoshan Hospital Shandong University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhua","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shandong Provincial Qianfoshan Hospital Shandong University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hesheng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shandong Provincial Qianfoshan Hospital Shandong University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrinne G.","family":"Lobe","sequence":"additional","affiliation":[{"name":"Miami Mice Research Corp.  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