{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T14:46:32Z","timestamp":1782744392786,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T00:00:00Z","timestamp":1444608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T00:00:00Z","timestamp":1444608000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>CBA\/J and CBA\/Ca mice are the recommended strains for local lymph node assays (LLNAs). Here, we report quantitative and qualitative comparisons between both mouse strains to provide useful information for the strain selection of sensitization testing. LLNA was conducted, in accordance with Organisation for Economic Co\u2010operation and Development Test Guideline No. 429, with CBA\/J and CBA\/Ca mice using five chemicals including typical contact sensitizers and non\u2010sensitizers: 2,4\u2010dinitrochlorobenzene (DNCB), isoeugenol, \u03b1\u2010hexylcinnamic aldehyde (HCA), propylene glycol (PG), and hexane; then outcomes were compared based on the raw data (disintegrations per minute, DPM), stimulation index (SI) values, EC3 values and positive\/negative decisions. Although a significant difference was noted between DPM values derived from each strain of mice, SI values exhibited no considerable difference. The EC3 values for DNCB in CBA\/J and CBA\/Ca mice were 0.04 and 0.03, those for isoeugenol were 1.4 and 0.9, and those for HCA were 7.7 and 6.0, respectively. All EC values derived from each test system were almost equivalent and were within the range of acceptance criteria of the ICCVAM performance standard for LLNA. Positive\/negative outcomes for all test chemicals were consistent. In conclusion, no considerable differences were observed in the final outcomes derived from CBA\/J and CBA\/Ca mice in LLNA. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.3250","type":"journal-article","created":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T20:08:11Z","timestamp":1444680491000},"page":"1011-1014","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of outcomes obtained in murine local lymph node assays using CBA\/J or CBA\/Ca mice"],"prefix":"10.1002","volume":"36","author":[{"given":"Yosuke","family":"Maeda","sequence":"first","affiliation":[{"name":"Chemicals Assessment and Research Center Chemicals Evaluation and Research Institute (CERI)  1600, Shimotakano, Sugito\u2010machi Kitakatsushika\u2010gun Saitama 345\u20100043 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Hirosaki","sequence":"additional","affiliation":[{"name":"Chemicals Assessment and Research Center Chemicals Evaluation and Research Institute (CERI)  1600, Shimotakano, Sugito\u2010machi Kitakatsushika\u2010gun Saitama 345\u20100043 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoaki","family":"Yakata","sequence":"additional","affiliation":[{"name":"Chemicals Assessment and Research Center Chemicals Evaluation and Research Institute (CERI)  1600, Shimotakano, Sugito\u2010machi Kitakatsushika\u2010gun Saitama 345\u20100043 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Takeyoshi","sequence":"additional","affiliation":[{"name":"Chemicals Assessment and Research Center Chemicals Evaluation and Research Institute (CERI)  1600, Shimotakano, Sugito\u2010machi Kitakatsushika\u2010gun Saitama 345\u20100043 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