{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:42:16Z","timestamp":1760575336833,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T00:00:00Z","timestamp":1450396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["No. 14YZ043","No. 14ZZ102"],"award-info":[{"award-number":["No. 14YZ043","No. 14ZZ102"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In recent years, the adverse health effects of decabrominated diphenyl ether (BDE\u2010209) have raised more concerns as a growing number of studies reported its persistence in the environment and abundance in the human population, especially in occupational environmental compartments and exposed personnel. This study applies our previous animal model simulating occupational exposure to BDE\u2010209 to investigate its potential adverse effects on CD4 T cells. Female C57Bl\/6 mice were orally gavaged with BDE\u2010209 at a dose of 800 mg kg<jats:sup>\u22121<\/jats:sup> every 2 days for 10 months and the blood of each mouse was collected for analysis. Kinetic changes of the peripheral immune system were investigated from 1 to 5 months of exposure. The chronic effects on cytokine production, proliferation and the antigen\u2010specific responses of CD4 T cells were evaluated at 7, 9 and 10 months, respectively. The results have shown that impaired proliferation and cytokine (IFN\u2010\u03b3, IL\u20102 or TNF\u2010\u03b1) production of CD4 T cells were observed in BDE\u2010209\u2010exposed mice, accompanied by increased T regulatory cells in the blood. BDE\u2010209 exposure <jats:italic>in vitro<\/jats:italic> also suppressed the reactivity of CD4 T cells at concentrations of 0.01, 0.1, 1 and 10 \u03bcM. Furthermore, we observed weaker antigen\u2010specific CD4 T\u2010cell responses to <jats:italic>Listeria monocytogenes<\/jats:italic> infection in the mice exposed to BDE\u2010209, suggesting decreased resistance to exogenous pathogens. Taken together, these observations indicate an impaired cellular immunity after long\u2010term and relative high\u2010dose exposure to BDE\u2010209 in adult mice. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.3270","type":"journal-article","created":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T20:40:37Z","timestamp":1450471237000},"page":"1112-1119","source":"Crossref","is-referenced-by-count":6,"title":["Long\u2010term exposure to high levels of decabrominated diphenyl ether inhibits CD4 T\u2010cell functions in C57Bl\/6 mice"],"prefix":"10.1002","volume":"36","author":[{"given":"Yan","family":"Feng","sequence":"first","affiliation":[{"name":"Faculty of Public Health Shanghai Jiao Tong University School of Medicine  Shanghai 200025 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihong","family":"Zeng","sequence":"additional","affiliation":[{"name":"Faculty of Public Health Shanghai Jiao Tong University School of Medicine  Shanghai 200025 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