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The goal of this study was to determine cadmium renal effects in rat fetuses by the quantification of early kidney injury biomarkers. Pregnant Wistar rats were exposed by inhalation to an isotonic saline solution or to CdCl<jats:sub>2<\/jats:sub> solution (D<jats:sub>Del<\/jats:sub>=1.48\u2009mg Cd kg<jats:sup>\u22121<\/jats:sup> day<jats:sup>\u22121<\/jats:sup>) during gestational days (GD) 8\u201320. On GD 21, dams were euthanized and samples obtained. Kidney injury biomarkers were quantified in amniotic fluid samples and fetal kidneys were microscopically evaluated to search for histological alterations. Our results showed that cadmium exposure significantly raised albumin, osteopontin, vascular endothelial growth factor and tissue inhibitor of metalloproteinases\u20101 levels in amniotic fluid, whereas it decreased creatinine. Clusterin, calbindin and IFN\u2010inducible protein 10 did not show any change. Accordingly, histological findings showed tubular damage and precipitations in the renal pelvis. In conclusion, gestational exposure to cadmium induces structural alterations in fetal renal tissue that can be detected by some kidney injury biomarkers in amniotic fluid samples. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.3286","type":"journal-article","created":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T01:27:02Z","timestamp":1453858022000},"page":"1183-1193","source":"Crossref","is-referenced-by-count":17,"title":["Evaluation of kidney injury biomarkers in rat amniotic fluid after gestational exposure to cadmium"],"prefix":"10.1002","volume":"36","author":[{"given":"Tania","family":"Jacobo\u2010Estrada","sequence":"first","affiliation":[{"name":"Departamento de Toxicolog\u00eda Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional  Av. Instituto Polit\u00e9cnico Nacional 2508, Col. 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