{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:05:07Z","timestamp":1792782307434,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T00:00:00Z","timestamp":1458000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Project of Science and Technology Agency of Jilin Province","award":["20140101002JC"],"award-info":[{"award-number":["20140101002JC"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Epidemiological studies show that particulate matter (PM) with an aerodynamic diameter\u2009\u2264\u20092.5\u2009\u03bcm (PM2.5) is associated with cardiorespiratory diseases via the induction of excessive oxidative stress. However, the precise mechanism underlying PM2.5\u2010mediated oxidative stress injury has not been fully elucidated. Accumulating evidence has indicated the microRNA let\u20107 family might play a role in PM\u2010mediated pathological processes. In this study, we investigated the role of let\u20107a in oxidative stress and cell injury in human bronchial epithelial BEAS2B (B2B) cells after PM2.5 exposure. The let\u20107a level was the most significantly decreased in B2B cells after PM2.5 exposure. The overexpression of let\u20107a suppressed intracellular reactive oxygen species levels and the percentage of apoptotic cells after PM2.5 exposure, while the let\u20107a level decreased arginase 2 (ARG2) mRNA and protein levels in B2B cells by directly targeting the ARG2 3\u2032\u2010untranslated region. ARG2 expression was upregulated in B2B cells during PM2.5 treatment, and ARG2 knockdown could remarkably reduce oxidative stress and cellular injury. Moreover, its restoration could abrogate the protective effects of let\u20107a against PM2.5\u2010induced injury. In conclusion, let\u20107a decreases and ARG2 increases resulting from PM2.5 exposure may exacerbate oxidative stress, cell injury and apoptosis of B2B cells. The let\u20107a\/ARG2 axis is a likely therapeutic target for PM2.5\u2010induced airway epithelial injury. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.3309","type":"journal-article","created":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T21:05:30Z","timestamp":1458335130000},"page":"1302-1310","source":"Crossref","is-referenced-by-count":40,"title":["Let\u20107a modulates particulate matter (\u2264 2.5\u2009\u03bcm)\u2010induced oxidative stress and injury in human airway epithelial cells by targeting arginase 2"],"prefix":"10.1002","volume":"36","author":[{"given":"Lei","family":"Song","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine The First Hospital of Jilin Universtity  71 the Xinmin Street Changchun People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The First Hospital of Jilin Universtity  71 the Xinmin Street Changchun People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The First Hospital of Jilin Universtity  71 the Xinmin Street Changchun People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The First Hospital of Jilin University  71 the Xinmin Street Changchun People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The First Hospital of Jilin Universtity  71 the Xinmin Street Changchun People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-13-52"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106540"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201165"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0901300"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.2987"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10473289.2001.10464287"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368914X678418"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2008.040857"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2013.05.004"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.091371"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-009-0747-5"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/15287394.2012.688479"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2015.07.011"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-135251"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2010.12.008"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1003369"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0305-0491(95)02138-8"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3965"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00007.2007"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703951"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00128-012-0827-0"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8977-10-63"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00057710"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-012-0858-4"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-12-19"},{"key":"e_1_2_8_27_1","first-page":"L96","article-title":"Induction of arginase isoforms in the lung during hyperoxia","volume":"275","author":"Que LG","year":"1998","journal-title":"Am. 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