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In spite of the known hepatotoxicity and genotoxicity of PFOA, correlation with PFOA and allergic inflammation is not well known. In this study, the effect of PFOA on the degranulation of mast cells and mast cell\u2010mediated allergic inflammation in the presence of Fc\u03b5RI cross\u2010linking was evaluated. In immunoglobulin (Ig) E\u2010stimulated mast cells, PFOA increased the release of histamine and \u03b2\u2010hexosaminidase by the up\u2010regulation of intracellular calcium levels. PFOA enhanced gene expression of several pro\u2010inflammatory cytokines, including tumor necrosis factor (TNF)\u2010\u03b1, interleukin (IL)\u20101\u03b2, IL\u20106, and IL\u20108 by the activation of nuclear factor (NF)\u2010\u03baB in IgE\u2010stimulated mast cells. Also, PFOA exacerbated allergic symptoms via hypothermia, and an increase of serum histamine, TNF\u2010\u03b1, IgE and IgG<jats:sub>1<\/jats:sub> in the ovalbumin\u2010induced systemic anaphylaxis. The present data indicate that PFOA aggravated Fc\u025bRI\u2010mediated mast cell degranulation and allergic symptoms. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.3389","type":"journal-article","created":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T04:49:22Z","timestamp":1475124562000},"page":"554-562","source":"Crossref","is-referenced-by-count":27,"title":["Association between perfluorooctanoic acid exposure and degranulation of mast cells in allergic inflammation"],"prefix":"10.1002","volume":"37","author":[{"given":"Jun\u2010Kyoung","family":"Lee","sequence":"first","affiliation":[{"name":"CMRI, Departments of Pharmacology Kyungpook National University  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"CMRI, Departments of Pharmacology Kyungpook National University  Daegu Republic of Korea"},{"name":"Natural Product Research Center, Research Institute of Bioscience and Biotechnology  Jeongeup Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon\u2010Chang","family":"Baek","sequence":"additional","affiliation":[{"name":"Molecular Medicine Kyungpook National University  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung\u2010Heon","family":"Lee","sequence":"additional","affiliation":[{"name":"Biochemistry and Cell Biology School of Medicine, Kyungpook National University  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun\u2010Shik","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Life Science, Kyungpook National University  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taeg Kyu","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Medicine, Keimyung University  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pil\u2010Hoon","family":"Park","sequence":"additional","affiliation":[{"name":"College of Pharmacy Yeungnam University  Gyeongsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae\u2010Yong","family":"Shin","sequence":"additional","affiliation":[{"name":"College of Pharmacy Woosuk University  Jeonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongwoo","family":"Khang","sequence":"additional","affiliation":[{"name":"Department of Physiology School of Medicine, Gachon University  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"CMRI, Departments of Pharmacology Kyungpook National University  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2011.09.007"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-12-14"},{"key":"e_1_2_8_4_1","volume-title":"ToxGuide\u2122 for Perfluoroalkyls","author":"ATSDR (Agency for Toxic Substances and Disease Registry)","year":"2015"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0901252"},{"key":"e_1_2_8_6_1","volume-title":"High levels of perfluorinated organic surfactants (PFT) in fish are harmless to health is not opinion","author":"BfR (Bundesinstitut f\u00fcr Risikobewertung; Federal Institute for Risk Assessment)","year":"2006"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.60"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/es070895g"},{"key":"e_1_2_8_9_1","unstructured":"COT (Committee on Toxicity of Chemicals in Food Consumer Products and the Environment).2006.COT statement on the tolerable daily intake for perfluorooctanoic acid.COT statement 2006\/10.http:\/\/www.food.gov.uk. 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