{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:49:10Z","timestamp":1782892150566,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T00:00:00Z","timestamp":1489622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["Grants\u2010in\u2010Aid for Scientific Research #23510076"],"award-info":[{"award-number":["Grants\u2010in\u2010Aid for Scientific Research #23510076"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Many concerns have been expressed regarding the possible adverse effects of thyroid hormone\u2010disrupting chemicals in the environment. The disruption of thyroid hormones in the neonatal period may lead to permanent effects on thyroid hormone homeostasis as well as related developmental disorders, as thyroid hormones are essential for regulating the growth and differentiation of many tissues. To understand the long\u2010term alteration in gene expressions by neonatal administration of thyroid hormone\u2010like chemicals in general, we identified genes whose expression was altered in the liver, an important component of the thyroid hormone axis, by neonatal exposure to triiodothyronine (T3). T3 was administered to male F344 rats on postnatal days 1, 3, and 5 (week 0). At 8\u2009weeks of age, cDNA microarray analysis was used to identify hepatic genes whose expression was altered by neonatal exposure to T3. Among the up\u2010regulated genes that were identified, the expression of <jats:italic>Olr59<\/jats:italic>, <jats:italic>Ethe1<\/jats:italic>, and <jats:italic>Slc10a2<\/jats:italic> increased specifically in rats neonatally exposed to T3. Interestingly, altered hepatic expression of these genes indeed increased when a hydroxylated polybrominated diphenyl ether (PBDE), OH\u2010BDE42, which is capable of binding to the TR, was given neonatally. Our data demonstrated that neonatal exposure to thyroid hormones could affect the long\u2010term expression of the genes, which could be useful markers for neonatal effects by thyroid hormone\u2010disrupting chemicals. Copyright \u00a9 2017 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.3452","type":"journal-article","created":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T04:48:49Z","timestamp":1489639729000},"page":"1030-1035","source":"Crossref","is-referenced-by-count":8,"title":["Altered expression of the <i>Olr59<\/i>, <i>Ethe1<\/i>, and <i>Slc10a2<\/i> genes in the liver of F344 rats by neonatal thyroid hormone disruption"],"prefix":"10.1002","volume":"37","author":[{"given":"Kana","family":"Matsubara","sequence":"first","affiliation":[{"name":"Faculty of Pharmaceutical Sciences \/ Graduate School of Biomedical Sciences Hiroshima University  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences \/ Graduate School of Biomedical Sciences Hiroshima University  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seigo","family":"Sanoh","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences \/ Graduate School of Biomedical Sciences Hiroshima University  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Ohta","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences \/ Graduate School of Biomedical Sciences Hiroshima University  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeyuki","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacology Nihon Pharmaceutical University  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Uramaru","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacology Nihon Pharmaceutical University  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Miyagawa","sequence":"additional","affiliation":[{"name":"Okazaki Institute for Integrative Bioscience National Institute for Basic Biology, National Institutes of Natural Sciences  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisen","family":"Iguchi","sequence":"additional","affiliation":[{"name":"Okazaki Institute for Integrative Bioscience National Institute for Basic Biology, National Institutes of Natural Sciences  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8570-4001","authenticated-orcid":false,"given":"Nariaki","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Endocrine Research Group, Department of Disease Model, Research Institute for Radiation Biology and Medicine (RIRBM) Hiroshima University  1\u20102\u20103 Kasumi, Minami\u2010ku, Hiroshima Hiroshima 734\u20108553 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,16]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"477","article-title":"Persistent thyrotropin insufficiency following neonatal thyroxine administration","volume":"67","author":"Bakke JL","year":"1966","journal-title":"J. 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