{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T03:45:44Z","timestamp":1773373544346,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T00:00:00Z","timestamp":1490227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Environmental pollutants may act as endocrine disruptors in animals. Organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) enter the food chain and may accumulate in the fatty animal tissues, including adrenals. To our knowledge, no previous study has investigated their presence in the human normal adrenal (NA) cortex and aldosterone\u2010producing adenomas (APA). Surgical fragments of APA from 11 patients and NA from 8 kidney donors were analyzed for 16 PCBs congeners and 10 OCPs. A Matrix Solid\u2010Phase Dispersion (MSPD) method for simultaneous determination of the target compounds in cortex homogenates was developed. A gas\u2010chromatography triple quadrupole mass spectrometry (Triple Quad GC\u2010MS) system was used for the analysis. Data were analyzed using Random Forest and Wilcoxon's rank\u2010sum test. OCPs and PCBs were found in specimens from both types. A subset of pollutants characterized APA more than NA. Higher concentrations (\u03bcg g<jats:sup>\u22121<\/jats:sup>) in APA were observed for \u03b1\u2010, \u03b2\u2010, and \u03b3\u2010 Hexachlorocyclohexane (HCH) (1.48 \u00b1 3.32 vs. 0.17 \u00b1 0.19, <jats:italic>P<\/jats:italic> = 0.028; 2.81 \u00b1 2.10 vs. 0.96 \u00b1 0.98, <jats:italic>P<\/jats:italic> = 0.011; 2.16 \u00b1 4.85 vs. 0.17 \u00b1 0.26, <jats:italic>P<\/jats:italic> = 0.004, respectively), as well as for Hexachlorobenzene (HCB) and for PCBs 28, 52 and 101 (3.41 \u00b1 3.11 vs. 0.97 \u00b1 1.06, <jats:italic>P<\/jats:italic> = 0.021; 2.34 \u00b1 4.68 vs. 0.25 \u00b1 0.22, <jats:italic>P<\/jats:italic> = 0.039; 0.58 \u00b1 1.19 vs. 0.06 \u00b1 0.02, <jats:italic>P<\/jats:italic> = 0.002; 0.26 \u00b1 0.43 vs. 0.05 \u00b1 0.00, <jats:italic>P<\/jats:italic> = 0.001, respectively). Environmental organochlorine pollutants were shown to be present in the human normal and abnormal adrenal cortex, deserving future investigation on their possible role as adrenal endocrine disruptors in human disease. Copyright \u00a9 2017 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.3460","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T02:50:17Z","timestamp":1490323817000},"page":"1091-1097","source":"Crossref","is-referenced-by-count":20,"title":["Evidence for persistent organochlorine pollutants in the human adrenal cortex"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6674-8036","authenticated-orcid":false,"given":"Enza","family":"Fommei","sequence":"first","affiliation":[{"name":"Fondazione Toscana \u201cGabriele Monasterio\u201d (FTGM)  Pisa Italy"},{"name":"Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Turci","sequence":"additional","affiliation":[{"name":"International Center of Toxicology Information Istituti Clinici Scientifici Maugeri  Pavia 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