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Their presence in human milk and their oestrogenic activity suggests a potential to influence breast cancer development. As metastatic tumour spread is the main cause of breast cancer mortality, we have investigated the effects of these compounds on migration and invasion of human breast cancer cell lines. Increased motility of oestrogen\u2010responsive MCF\u20107 human breast cancer cells was observed after long\u2010term exposure (&gt;20\u00a0weeks) to each of the six compounds at \u226510<jats:sup>\u22127<\/jats:sup>\u00a0<jats:sc>m<\/jats:sc> concentrations using three independent assay systems (scratch assay, live cell imaging, xCELLigence technology) and increased invasive activity was observed through matrigel using the xCELLigence system. Increased motility of oestrogen\u2010unresponsive MDA\u2010MB\u2010231 human breast cancer cells was observed after 15\u00a0weeks of exposure to each of the six compounds by live cell imaging and xCELLigence technology, implying the increased migratory activity was not confined to oestrogen\u2010responsive cells. Molecular mechanisms varied between compounds and cell lines. Using MCF\u20107 cells, reduction in E\u2010cadherin was observed following 24\u00a0weeks' exposure to 10<jats:sup>\u22125<\/jats:sup>\u00a0<jats:sc>m<\/jats:sc> BP\u20101 and 10<jats:sup>\u22125<\/jats:sup>\u00a0<jats:sc>m<\/jats:sc> homosalate, and reduction in \u03b2\u2010catenin was noted following 24\u00a0weeks' exposure to 10<jats:sup>\u22125<\/jats:sup>\u00a0<jats:sc>m<\/jats:sc> OMC. Using MDA\u2010MB\u2010231 cells, increased levels of matrix metalloproteinase 2 were observed after 15\u00a0weeks exposure to 10<jats:sup>\u22127<\/jats:sup>\u00a0<jats:sc>m<\/jats:sc> OMC and 10<jats:sup>\u22127<\/jats:sup>\u00a0<jats:sc>m<\/jats:sc> 4\u2010methylbenzilidenecamphor. Although molecular mechanisms differ, these results demonstrate that exposure to any of these six compounds can increase migration and invasion of human breast cancer cells.<\/jats:p>","DOI":"10.1002\/jat.3525","type":"journal-article","created":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T03:21:46Z","timestamp":1507519306000},"page":"148-159","source":"Crossref","is-referenced-by-count":57,"title":["Effects of exposure to six chemical ultraviolet filters commonly used in personal care products on motility of MCF\u20107 and MDA\u2010MB\u2010231 human breast cancer cells in vitro"],"prefix":"10.1002","volume":"38","author":[{"given":"Maha","family":"Alamer","sequence":"first","affiliation":[{"name":"School of Biological Sciences University of Reading  Reading RG6 6UB UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2056-3383","authenticated-orcid":false,"given":"Philippa D.","family":"Darbre","sequence":"additional","affiliation":[{"name":"School of Biological Sciences University of Reading  Reading RG6 6UB UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,9]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Alamer M. 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