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The aim of the present study is therefore to evaluate the protective effect of Bendavia, a novel antioxidant, on gentamicin\u2010induced hair cell damage in zebrafish lateral lines. The results demonstrated the pretreatment of Bendavia exhibited dose\u2010dependent protection against gentamicin in both acute and chronic exposure. We found that Bendavia at 150\u00a0\u03bc<jats:sc>m<\/jats:sc> conferred optimal protection from either acute or chronic exposure with ototoxin. Bendavia reduced uptake of fluorescent\u2010tagged gentamicin via mechanoelectrical transduction channels, suggesting its protective effects may be partially due to decreasing ototoxic molecule uptake. The intracellular death pathways inhibition triggered by gentamicin might be also included as no blockage of gentamicin was observed. Our data suggest that Bendavia represents a novel otoprotective drug that might provide a therapeutic alternative for patients receiving aminoglycoside treatment.<\/jats:p>","DOI":"10.1002\/jat.3547","type":"journal-article","created":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T12:14:28Z","timestamp":1509711268000},"page":"376-384","source":"Crossref","is-referenced-by-count":6,"title":["A mitochondrial targeting tetrapeptide Bendavia protects lateral line hair cells from gentamicin exposure"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8230-4021","authenticated-orcid":false,"given":"Xiao","family":"Kuang","sequence":"first","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University  Shenyang 110016 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhui","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University  Shenyang 110016 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenjie","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University  Shenyang 110016 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University  Shenyang 110016 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongzhuo","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University  Shenyang 110016 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2011.647359"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12468"},{"key":"e_1_2_7_4_1","first-page":"520","article-title":"Clinical forum: A review of intratympanic therapy","volume":"18","author":"Blakley B. 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