{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T20:06:57Z","timestamp":1772050017015,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T00:00:00Z","timestamp":1510876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81202237"],"award-info":[{"award-number":["81202237"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Arsenic is an established human carcinogen but with weak mutagenic activity. The mechanisms of arsenic\u2010induced carcinogenesis are not well understood. In the present study, we investigated the role of histone methylation in transformation of human bronchial epithelial (BEAS\u20102B) cells. After 16\u00a0weeks\u2019 exposure, cells were transformed by 0.1, 0.5 and 1\u00a0\u03bc<jats:sc>m<\/jats:sc> arsenite. Global trimethylated H3K4 (H3K4me3) was decreased by 0.1\u00a0\u03bc<jats:sc>m<\/jats:sc> arsenite at 12\u00a0weeks, and 0.5 and 1\u00a0\u03bc<jats:sc>m<\/jats:sc> arsenite at 8, 12 and 16\u00a0weeks, which could be attributed to reduced histone methyltransferase activities, increased histone demethylase (HDM) activities as well as increased protein levels of H3K4 demethylase KDM5A. Global dimethylated H3K9 (H3K9me2) was also decreased after exposure to 0.5\u00a0\u03bc<jats:sc>m<\/jats:sc> arsenite for 4, 8, 12 and 16\u00a0weeks and 1.0\u00a0\u03bc<jats:sc>m<\/jats:sc> arsenite for 8 and 12\u00a0weeks, which was associated with an increase of HDM activities. Our findings indicated that arsenite decreased global H3K4me3 and H3K9me2 levels during cell transformation by modulating the enzymatic activities of histone methyltransferases and\/or HDMs, and by upregulation of KDM5A protein levels for H3K4me3.<\/jats:p>","DOI":"10.1002\/jat.3555","type":"journal-article","created":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T07:06:44Z","timestamp":1510902404000},"page":"480-488","source":"Crossref","is-referenced-by-count":9,"title":["Arsenite downregulates H3K4 trimethylation and H3K9 dimethylation during transformation of human bronchial epithelial cells"],"prefix":"10.1002","volume":"38","author":[{"given":"Wei","family":"Tu","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education, School of Public Health, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei 430030 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education, School of Public Health, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei 430030 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengfeng","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education, School of Public Health, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei 430030 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8254-9341","authenticated-orcid":false,"given":"Xue","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education, School of Public Health, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei 430030 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2017.04.012"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-015-1605-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10644"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.05.009"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.09.102"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1999.tb00660.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1652908"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfj159"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2005.08.011"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/em.2860070515"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgn102"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2008.10.013"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfr256"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(85)90155-3"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25538"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2014.11.001"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi172"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5742(97)00008-2"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2015.04.002"},{"key":"e_1_2_7_21_1","doi-asserted-by":"crossref","DOI":"10.1038\/srep37227","article-title":"Oncogenic transformation of human lung bronchial epithelial cells induced by arsenic involves ROS\u2010dependent activation of STAT3\u2010miR\u201021\u2010PDCD4 mechanism","volume":"6","author":"Pratheeshkumar P.","year":"2016","journal-title":"Scientific Reports"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1002114"},{"key":"e_1_2_7_23_1","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/S1097-2765(03)00479-9","article-title":"Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains","volume":"12","author":"Rice J. 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