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Following treatment with 300\u00a0\u03bc<jats:sc>m<\/jats:sc> MPTP, a total of 576 miRNAs were dysregulated, of which 506 were upregulated and 70 were downregulated. Alterations in the expression of miR\u201017\u20105p, miR\u2010210\u20103p, miR\u2010374\u20105p, miR\u2010378\u20103p and miR\u2010503\u20105p were verified by real\u2010time quantitative reverse transcriptase polymerase chain reaction. Moreover, overexpression of miR\u201017\u20105p in Neuro\u20102a cells enhanced cell proliferation, suppressed apoptosis and promoted S phase transition of the cell cycle after PQ treatment. Taken together, our study demonstrates that characteristic changes in miRNA expression profiles occur after PQ and MPTP treatment, which suggests that miRNAs may be involved in the development of PQ\u2010 and MPTP\u2010induced neurodegeneration. Downregulated miR\u201017\u20105p expression contributes to PQ\u2010induced dopaminergic neurodegeneration.<\/jats:p>","DOI":"10.1002\/jat.3571","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T01:44:42Z","timestamp":1513561482000},"page":"665-677","source":"Crossref","is-referenced-by-count":34,"title":["Paraquat and MPTP alter microRNA expression profiles, and downregulated expression of miR\u201017\u20105p contributes to PQ\u2010induced dopaminergic neurodegeneration"],"prefix":"10.1002","volume":"38","author":[{"given":"Qingqing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health Fujian Medical University  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