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Rosuvastatin is a lipid\u2010lowering drug and has been indicated to prevent cardiovascular diseases and to treat dyslipidemias due to its higher efficiency to reduce serum cholesterol concentrations. This study aimed to evaluate the reproductive adverse effects on sexual maturity due to rosuvastatin exposure in juvenile male rats during prepuberty. Three groups were randomly formed with newly weaned rats: control, whose rats received saline solution 0.9% and rosuvastatin at doses of 3 or 10\u00a0mg kg<jats:sup>\u20131<\/jats:sup> day<jats:sup>\u20131<\/jats:sup>, administered orally by gavage, from postnatal day 21 until preputial separation (average of 45\u00a0days for controls and 49\u00a0days for statin\u2010treated animals), indicative of puberty onset. Male rats were maintained until sexual maturity and were killed on postnatal day 110. In the rosuvastatin\u2010treated groups, the results showed diminished follicle\u2010stimulating hormone, luteinizing hormone and testosterone concentrations, increased estradiol and prolactin concentrations, histopathologic alterations on testis and epididymis and decreased sperm quality. Moreover, statin\u2010exposed groups showed decreased expression of androgen receptor on testis and epididymis and lower expression of aquaporin\u20109 on epididymal epithelium. In conclusion, administration of rosuvastatin to prepubertal male rats provoked long\u2010term hormonal deregulation and impaired reproduction at adulthood.<\/jats:p>","DOI":"10.1002\/jat.3599","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T13:31:23Z","timestamp":1519219883000},"page":"914-929","source":"Crossref","is-referenced-by-count":23,"title":["Lower sperm quality and testicular and epididymal structural impairment in adult rats exposed to rosuvastatin during prepuberty"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9437-6310","authenticated-orcid":false,"given":"Gabriel Adan Ara\u00fajo","family":"Leite","sequence":"first","affiliation":[{"name":"Department of Morphology S\u00e3o Paulo State University (UNESP), Institute of Biosciences  Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marciana","family":"Sanabria","sequence":"additional","affiliation":[{"name":"Department of Morphology S\u00e3o Paulo State University (UNESP), Institute of Biosciences  Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilia Martins","family":"Cavariani","sequence":"additional","affiliation":[{"name":"Department of Morphology S\u00e3o Paulo State University (UNESP), Institute of Biosciences  Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janete Aparecida","family":"Anselmo\u2010Franci","sequence":"additional","affiliation":[{"name":"Department of Morphology, Stomatology and Physiology, School of Dentistry USP \u2013 University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Fernanda Felipe","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Department of Anatomy S\u00e3o Paulo State University (UNESP), Institute of Biosciences  Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel Fantin","family":"Domeniconi","sequence":"additional","affiliation":[{"name":"Department of Anatomy S\u00e3o Paulo State University (UNESP), Institute of Biosciences  Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilma De Grava","family":"Kempinas","sequence":"additional","affiliation":[{"name":"Department of Morphology S\u00e3o Paulo State University (UNESP), Institute of Biosciences  Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(84)80111-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12461"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.10.044"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.2002.tb02243.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(87)90098-0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210\u2010016\u20101252\u20104"},{"key":"e_1_2_7_8_1","first-page":"77","article-title":"Statins and mitochondria","volume":"62","author":"Broniarek I.","year":"2016","journal-title":"Post\u0119py Biochemii"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","unstructured":"Celis J. 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