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However, the renal excretion pathway of drugs has not been fully elucidated at different stages of renal injury. This study aimed to evaluate the alteration of renal excretion pathways in gentamicin (GEN)\u2010induced renal injury in rats. Results showed that serum cystatin C, creatinine and urea nitrogen levels were greatly increased by the exposure of GEN (100\u00a0mg kg<jats:sup>\u20131<\/jats:sup>), and creatinine concentration was increased by 39.7% by GEN (50\u00a0mg kg<jats:sup>\u20131<\/jats:sup>). GEN dose\u2010dependently upregulated the protein expression of rOCT1, downregulated rOCT2 and rOAT1, but not affected rOAT2. Efflux transporters, rMRP2, rMRP4 and rBCRP expressions were significantly increased by GEN(100), and the rMATE1 level was markedly increased by GEN(50) but decreased by GEN(100). GEN(50) did not alter the urinary excretion of inulin, but increased metformin and furosemide excretion. However, GEN(100) resulted in a significant decrease of the urinary excretion of inulin, metformin and <jats:italic>p<\/jats:italic>\u2010aminohippurate. In addition, urinary metformin excretions in vivo were significantly decreased by GEN(100), but slightly increased by GEN(50). These results suggested that GEN(50) resulted in the induction of rOCTs\u2010rMATE1 and rOAT3\u2010rMRPs pathway, but not changed the glomerular filtration rate, and GEN(100)\u2010induced acute kidney injury caused the downregulated function of glomerular filtration \u2010rOCTs\u2010rMATE1 and \u2010rOAT1\u2010rMRPs pathway.<\/jats:p>","DOI":"10.1002\/jat.3603","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T13:12:07Z","timestamp":1519391527000},"page":"968-977","source":"Crossref","is-referenced-by-count":7,"title":["Alteration of renal excretion pathways in gentamicin\u2010induced renal injury in rats"],"prefix":"10.1002","volume":"38","author":[{"given":"Yan\u2010rong","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Pharmacy the First Hospital of Lanzhou University  Lanzhou 730000 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