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Autophagy, playing a crucial role in various physiopathological conditions, modulates cellular homeostasis and stress adaptation. Resveratrol is a phytoalexin that exerts potent antioxidant effects on cardiopulmonary diseases. To date, the mechanisms by which resveratrol protects against PM<jats:sub>2.5<\/jats:sub> remain to be elucidated. In the present study, we investigated the effect of resveratrol on PM<jats:sub>2.5<\/jats:sub>\u2010induced oxidative injury. The potential role of nuclear factor erythroid\u20102\u2010related factor 2 and autophagy in this progress was explored. Human bronchial epithelial cells were treated with PM<jats:sub>2.5<\/jats:sub> and the cytotoxicity and oxidative stress markers were determined. The results showed that PM<jats:sub>2.5<\/jats:sub> decreased cell viability and elevated the level of lactate dehydrogenase. The levels of malondialdehyde and reactive oxygen species were increased by PM<jats:sub>2.5<\/jats:sub> exposure. PM<jats:sub>2.5<\/jats:sub> also induced a significant increase of the inflammatory cytokines including interleukin (IL)\u20106, IL\u20108, IL\u20101\u03b2 and tumor necrosis factor \u03b1. Meanwhile, PM<jats:sub>2.5<\/jats:sub> triggered autophagy formation and alteration of the nuclear factor erythroid\u20102\u2010related factor 2 pathway. Furthermore, human bronchial epithelial cells were co\u2010treated with PM<jats:sub>2.5<\/jats:sub> and resveratrol in the presence or absence of 3\u2010methylamphetamine, an inhibitor of autophagic formation. It was revealed that resveratrol intervention abolished PM<jats:sub>2.5<\/jats:sub>\u2010induced oxidative injury partially through the suppression of autophagy deregulation. Findings from this study could provide new insights into the molecular mechanisms of pulmonary intervention during PM<jats:sub>2.5<\/jats:sub> exposure.<\/jats:p>","DOI":"10.1002\/jat.3636","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T02:35:38Z","timestamp":1526870138000},"page":"1251-1261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Resveratrol relieves particulate matter (mean diameter &lt; 2.5 \u03bcm)\u2010induced oxidative injury of lung cells through attenuation of autophagy deregulation"],"prefix":"10.1002","volume":"38","author":[{"given":"Yuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Safety, School of Public Health Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Qian","sequence":"additional","affiliation":[{"name":"Department 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