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ZEA was exposed to female zebrafish for 21\u00a0days to assess growth indices such as condition factor, hepatosomatic index, gonadosomatic index and caspase 3 activity. Further, expression of estrogen receptor (ER) \u03b1 and CYP19a1b genes in the brain, ER\u03b1 and vitellogenin (Vtg) genes in the liver and follicle\u2010stimulating hormone receptor, luteinizing hormone receptor, ER\u03b1, steroidogenic acute regulatory protein, 3\u03b2\u2010hydroxysteroid dehydrogenase (HSD), 17\u2010\u03b2HSD and CYP19a1 genes in the ovary were also investigated. Our results showed that there were no significant changes in the condition factor and hepatosomatic index, whereas a significant (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05) reduction in the gonadosomatic index, increase in caspase 3 activities and Vtg expression was observed at higher concentration. However, no significant changes were observed at lower treatment levels. Further, we also observed significant (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05) upregulation in ER\u03b1, Vtg, luteinizing hormone receptor, steroidogenic acute regulatory protein, 3\u03b2\u2010HSD, 17\u03b2\u2010HSD, CYP19a1 and CYP19a1b genes in treatment groups with higher levels of ZEA. Moreover, in histopathological examination, we observed oocyte atresia and oocyte membrane detachment in ovaries at the highest concentration. In conclusion, the present study revealed the negative impact of ZEA on zebrafish reproductive system by involvement of the hypothalamic\u2013pituitary\u2013gonadal axis\u2010associated reproductive function.<\/jats:p>","DOI":"10.1002\/jat.3652","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T23:26:18Z","timestamp":1529450778000},"page":"1388-1397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Mycotoxin zearalenone induced gonadal impairment and altered gene expression in the hypothalamic\u2013pituitary\u2013gonadal axis of adult female zebrafish (<scp><i>Danio rerio<\/i><\/scp>)"],"prefix":"10.1002","volume":"38","author":[{"given":"Sellamani","family":"Muthulakshmi","sequence":"first","affiliation":[{"name":"Toxicology and Immunology Division, DRDO\u2010BU Centre for Life Sciences Bharathiar University Campus  Coimbatore 641046 Tamil Nadu India"},{"name":"Department of Biological Sciences University of Calgary  2500 University Drive NW Calgary AB Canada T2N 1N4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pourmohammadi Fallah","family":"Hamideh","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences University of Calgary  2500 University Drive NW Calgary AB Canada T2N 1N4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid R.","family":"Habibi","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences University of Calgary  2500 University Drive NW Calgary AB Canada T2N 1N4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kannan","family":"Maharajan","sequence":"additional","affiliation":[{"name":"Toxicology and Immunology Division, DRDO\u2010BU Centre for Life Sciences Bharathiar University Campus  Coimbatore 641046 Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Kadirvelu","sequence":"additional","affiliation":[{"name":"Toxicology and Immunology Division, DRDO\u2010BU Centre for Life Sciences Bharathiar University Campus  Coimbatore 641046 Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0545-2893","authenticated-orcid":false,"given":"Venkataramana","family":"Mudili","sequence":"additional","affiliation":[{"name":"Toxicology and Immunology Division, DRDO\u2010BU Centre for Life Sciences Bharathiar University Campus  Coimbatore 641046 Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.45.4.469"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0048-9697(99)00275-2"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2013.03.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-013-1474-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.16.3.497-516.2003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/19440049.2012.672476"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2008.03.010"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2016.09.015"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.12.022"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2013.04.009"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2014.06.004"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2008.11.042"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-9936(98)00020-X"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/es8007326"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2011.09.021"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfh191"},{"key":"e_1_2_8_18_1","series-title":"Joint FAO\/WHO Expert Committee on Food Additives. 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