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Carcinogenicity caused by long\u2010term exposure to 1,2\u2010DCP is well established. However, the possible liver damage and related toxic mechanisms associated with acute inhalation exposure to 1,2\u2010DCP are rarely reported. In this study, we investigated the effects of individual and combined exposure to 1,2\u2010DCP and dichloromethane (DCM) on mice liver. The results showed that 1,2\u2010DCP significantly caused liver necrosis, possibly due to 1,2\u2010DCP\u2010induced inhibition of the mitochondrial respiratory chain complex I\u2010IV activities, resulting in mitochondrial dysfunction and extreme ATP consumption. Moreover, 1,2\u2010DCP also decreased mitochondrial defense ability by inhibiting the mitochondrial glutathione <jats:italic>S<\/jats:italic>\u2010transferase 1 (MGST1) activity, further aggravating liver damage. Additionally, we found that DCM co\u2010exposure potentially enhanced 1,2\u2010DCP toxicity. Our findings suggest that inhibition of mitochondrial function and MGST1 activity play critical roles in modulating 1,2\u2010DCP\u2010induced liver damage. Furthermore, our results contribute to study the new mechanism of mitochondria\u2010dominated signaling pathways underlying liver injury induced by 1,2\u2010DCP and DCM.<\/jats:p>","DOI":"10.1002\/jat.3715","type":"journal-article","created":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T22:14:10Z","timestamp":1537568050000},"page":"260-270","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Acute inhalation co\u2010exposure to 1,2\u2010dichloropropane and dichloromethane cause liver damage by inhibiting mitochondrial respiration and defense ability in mice"],"prefix":"10.1002","volume":"39","author":[{"given":"Hufei","family":"Wang","sequence":"first","affiliation":[{"name":"College of Biological Science and Engineering Fuzhou University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiamin","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Biological Science and Engineering Fuzhou University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Suda","sequence":"additional","affiliation":[{"name":"Japan National Institute of Occupational Safety and Health  Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukie","family":"Yanagiba","sequence":"additional","affiliation":[{"name":"Japan National Institute of Occupational Safety and Health  Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1089-8673","authenticated-orcid":false,"given":"Zuquan","family":"Weng","sequence":"additional","affiliation":[{"name":"College of Biological Science and Engineering Fuzhou University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui\u2010Sheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Japan National Institute of Occupational Safety and Health  Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/gex014"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)61028-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2490819"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70316-X"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0272-0590(89)90003-1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.12.022"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph8083380"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.2550100602"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.40.647"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfv045"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3416"},{"key":"e_1_2_7_13_1","unstructured":"International Agency for Research on Cancer (IARC)(1999a).1 2\u2010Dichloropropane. 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