{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:49:31Z","timestamp":1777506571647,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T00:00:00Z","timestamp":1536883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008569","name":"Oklahoma Center for the Advancement of Science and Technology","doi-asserted-by":"publisher","award":["6552"],"award-info":[{"award-number":["6552"]}],"id":[{"id":"10.13039\/100008569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 150\u2010day post\u2010metamorphosis (dpm) partial lifecycle study exposing <jats:styled-content style=\"fixed-case\"><jats:italic>Silurana tropicalis<\/jats:italic><\/jats:styled-content> to &lt;0.03 (control), 0.06, 0.13 0.25, 0.5 and 1.0\u00a0mg\/L perfluorooctanesulfonate (PFOS) was conducted. A subset of specimens from the control and each treatment were evaluated at metamorphic completion. A significant increase in the median metamorphosis time was observed in the 1.0\u00a0mg\/L PFOS treatment relative to the control. A modest increase in the occurrence, but not severity, of mild follicular hypertrophy was found in thyroid glands from organisms exposed to the 0.62 and 1.1\u00a0mg\/L PFOS treatments. At 150\u00a0dpm, a concentration\u2010dependent increase in whole body PFOS residues was measured ranging from 29.6 to 163.5\u00a0mg\/kg in the 0.05 and 1.1\u00a0mg\/L PFOS treatments. Decreased body weight and snout\u2010vent length were noted in specimens exposed to 1.1\u00a0mg PFOS\/L at the completion of metamorphosis. Body weight was reduced in the 1.1\u00a0mg\/L PFOS concentration; however, snout\u2010vent length was not affected by PFOS exposure at 150\u00a0dpm. An increased proportion of phenotypic males were noted in the 0.62 and 1.1\u00a0mg\/L PFOS treatments. Abnormal ovary development characterized by size asymmetry, necrosis and formation of excessive fibrous connective tissue was identified in females exposed to 0.29 and 1.1\u00a0mg PFOS\/L. Asymmetrically misshaped testes were found at 1.1\u00a0mg\/L PFOS. Results suggested that PFOS is capable of interfering with <jats:styled-content style=\"fixed-case\"><jats:italic>S. tropicalis<\/jats:italic><\/jats:styled-content> growth before metamorphic completion and growth and gonad development during juvenile development.<\/jats:p>","DOI":"10.1002\/jat.3727","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T04:28:46Z","timestamp":1537072126000},"page":"365-374","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Evaluation of the developmental toxicity of perfluorooctanesulfonate in the Anuran, <scp><i>Silurana tropicalis<\/i><\/scp>"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9071-014X","authenticated-orcid":false,"given":"Douglas J.","family":"Fort","sequence":"first","affiliation":[{"name":"Fort Environmental Laboratories  Stillwater OK USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B.","family":"Mathis","sequence":"additional","affiliation":[{"name":"Fort Environmental Laboratories  Stillwater OK USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick D.","family":"Guiney","sequence":"additional","affiliation":[{"name":"S.C. 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