{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:16:37Z","timestamp":1790716597537,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T00:00:00Z","timestamp":1557187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007869","name":"Department of Forestry and Natural Resources, Purdue University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007869","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011592","name":"Office of the Executive Vice President for Research and Partnerships, Purdue University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Several halogenated chemicals are found in an array of products that can cause endocrine disruption. Human studies have shown that endocrine responses are sex specific, with females more likely to develop hypothyroidism and males more likely to have reproductive impairment. The objective of this study was to assess sex differences on thyroid and estrogenic effects after exposure of Japanese medaka (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Oryzias latipes<\/jats:italic>\n                    <\/jats:styled-content>\n                    , SK2MC) to halogenated compounds. This strain is an excellent model for these studies as sex can be determined non\u2010destructively a few hours postfertilization. Medaka embryos were exposed to sublethal concentrations of Tris(1,3\u2010dichloro\u20102\u2010propyl) phosphate (TDCPP, 0.019\u00a0mg\/L), perfluorooctanoic acid (PFOA, 4.7\u00a0mg\/L) and its next generation alternative, perfluorobutyric acid (PFBA, 137\u00a0mg\/L). Methimazole (inhibits thyroid hormone synthesis) and the thyroid hormone triiodothyronine served as reference controls. Fish were exposed throughout embryo development until 10\u00a0days postfertilization. Females displayed significantly larger swim bladders (which are under thyroid hormone control) after exposure to all chemicals with the exception of triiodothyronine, which caused the opposite effect. Females exposed to TDCPP and PFOA had increased expression of vitellogenin and exposure to PFOA upregulated expression of multiple thyroid\u2010related genes. Upregulation of estrogenic\u2010regulated genes after exposure to TDCPP, PFOA and methimazole was only observed in males. Overall, our results suggest that females and males show an estrogenic response when exposed to these halogenated chemicals and that females appear more susceptible to thyroid\u2010induced swim bladder dysfunction compared with males. These results further confirm the importance of considering sex effects when assessing the toxicity of endocrine\u2010disrupting compounds.\n                  <\/jats:p>","DOI":"10.1002\/jat.3807","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T01:55:23Z","timestamp":1557280523000},"page":"1215-1223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Sex\u2010specific endocrine\u2010disrupting effects of three halogenated chemicals in Japanese medaka"],"prefix":"10.1002","volume":"39","author":[{"given":"Amy","family":"Godfrey","sequence":"first","affiliation":[{"name":"Department of Forestry and Natural Resources Purdue University  West Lafayette Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5897-9042","authenticated-orcid":false,"given":"Blair","family":"Hooser","sequence":"additional","affiliation":[{"name":"Department of Forestry and Natural Resources Purdue University  West Lafayette Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7128-8334","authenticated-orcid":false,"given":"Ahmed","family":"Abdelmoneim","sequence":"additional","affiliation":[{"name":"Department of Forestry and Natural Resources Purdue University  West Lafayette Indiana"},{"name":"Department of Veterinary Forensic Medicine &amp; Toxicology Assiut University  Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria S.","family":"Sep\u00falveda","sequence":"additional","affiliation":[{"name":"Department of Forestry and Natural Resources Purdue University  West Lafayette Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2019.01.013"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/etc.3032"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/etc.2663"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200106073442302"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfq379"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2012.02.001"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00244-005-0319-x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2005.12.005"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2017.04.146"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2017.10.024"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1306902"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8068"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/342189"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2017.04.013"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2007.02.011"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2017.06.024"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2013.12.064"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2007.09.009"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2012.12.010"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-0436.2002.700104.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/56.1.95"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2015.12.024"},{"key":"e_1_2_9_24_1","unstructured":"NIEHS. 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