{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T16:34:14Z","timestamp":1768926854868,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T00:00:00Z","timestamp":1557187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Indoor dust contains a multitude of industrial chemicals, and ingestion of dust is considered an important exposure route to organic contaminants. Some of these contaminants have been shown to interfere with the thyroid system, which may result in significant consequences on public health. The amphibian metamorphosis is a thyroid hormone\u2010dependent process, which can be used as an in vivo model for studies on thyroid hormone\u2010disrupting potency. Three contaminants of indoor dust were tested on metamorphosing <jats:italic>Silurana (Xenopus) tropicalis<\/jats:italic> tadpoles. The tested chemicals were Tris (1,3\u2010dichloroisopropyl) phosphate (TDCiPP), tetrabromobisphenol\u2010A (TBBPA) and propylparaben (PrP). Measurements reflecting general growth, development progress and thyroid epithelial cell height were performed on the exposed tadpoles as well as chemical analyses of the exposure water. It was shown that TDCiPP acts as a thyroid hormone\u2010disrupting chemical in metamorphosing tadpoles by causing increased epithelial cell height in thyroid glands after exposure to a nominal concentration of 0.010\u00a0mg\/L and in higher concentrations. TBBPA caused reductions in general growth of tadpoles at the nominal concentration 0.125\u00a0mg\/L, and PrP caused acute toxicity at the nominal concentration 12.5\u00a0mg\/L. However, no evident indications of specific thyroid\u2010disrupting effects caused by TBBPA or PrP were observed.<\/jats:p>","DOI":"10.1002\/jat.3810","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T01:55:06Z","timestamp":1557280506000},"page":"1248-1256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Thyroid disruption properties of three indoor dust chemicals tested in <scp><i>Silurana tropicalis<\/i><\/scp> tadpoles"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2681-3726","authenticated-orcid":false,"given":"Gunnar","family":"Carlsson","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences and Veterinary Public Health Swedish University of Agricultural Sciences  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Pohl","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Veterinary Public Health Swedish University of Agricultural Sciences  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Athanassiadis","sequence":"additional","affiliation":[{"name":"Department of Environmental Science and Analytical Chemistry Stockholm University  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leif","family":"Norrgren","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Veterinary Public Health Swedish University of Agricultural Sciences  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Environmental Science and Analytical Chemistry Stockholm University  Stockholm Sweden"},{"name":"Department of Aquatic Sciences and Assessment Swedish University of Agricultural Sciences  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,7]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Bergman \u00c5. Heindel J. J. Jobling S. Kidd K. A. &ZoellerR. T.(2013).\u2009State of the Science of Endocrine Disrupting Chemicals\u20102012. United Nations Environment Programme and the World Health Organization. ISBN: 978\u201092\u2010807\u20103274\u20100 (UNEP) and 978\u201092\u20104\u2010150503\u20101 (WHO)."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.09.005"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/074823379801400107"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.03.021"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.3.1287"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2007.01.005"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2007.06.003"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1897\/08-524.1"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrb.21081"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2018.10.028"},{"key":"e_1_2_6_12_1","unstructured":"deBenoist B. Andersson M. Egli I. Takkouche B. &Allen H.(2004).Iodine status worldwide WHO Global Database on Iodine Deficiency. Geneva: Department of Nutrition for Health and Development World Health Organization."},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kft100"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/es0704129"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2014.06.016"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2409"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfj187"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2017.07.015"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfp086"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.3.962"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/15287394.2017.1336414"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2005.09.006"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/es048267b"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.8b00727"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1248\/jhs.49.99"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.08.030"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2016.05.018"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2018.02.161"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1002238"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/56.1.95"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/es200925h"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1293\/tox.25.1"},{"key":"e_1_2_6_33_1","volume-title":"Normal table of Xenopus laevis","author":"Nieuwkoop P. D.","year":"1994"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.6b05025"},{"key":"e_1_2_6_35_1","unstructured":"OECD (Organisation for Economic Co\u2010operation and Development)(2009).\u2009The Amphibian Metamorphosis Assay. OECD guideline for the testing of chemicals. Guideline 231."},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/joa.12303"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01963218"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2015.03.011"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2012.08.034"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016709"},{"key":"e_1_2_6_41_1","first-page":"267","volume-title":"Vogel's elementary practical organic chemistry 1: Preparations","author":"Smith B. V.","year":"1980"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1897\/04-105R.1"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2010.01.013"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2012.11.009"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2014.10.009"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.5b01742"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5TX00374A"}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjat.3810","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.3810","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jat.3810","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.3810","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:44:01Z","timestamp":1760550241000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.3810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,7]]},"references-count":46,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1002\/jat.3810"],"URL":"https:\/\/doi.org\/10.1002\/jat.3810","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"value":"0260-437X","type":"print"},{"value":"1099-1263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,7]]},"assertion":[{"value":"2019-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}