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We hypothesized that the effect of prenatal exposure to environmentally relevant doses of BPA will be evident during fetal organogenesis and fetal\/postnatal growth trajectory. Pregnant ewes were administered BPA subcutaneously from 30 to 90\u00a0days of gestation (term 147\u00a0days). Fetal organ weight, anthropometric measures, maternal\/fetal hormones and postnatal growth trajectory were measured in both sexes. Gestational BPA administration resulted in higher accumulation in male than female fetuses only at fetal day 65, with minimal impact on fetal\/maternal steroid milieu in both sexes at both time points. BPA\u2010treated male fetuses were heavier than BPA\u2010treated female fetuses at fetal day 90 whereas this sex difference was not evident in the control group. At the organ level, liver weight was reduced in prenatal BPA\u2010treated female fetuses, while heart and thyroid gland weights were increased in BPA\u2010treated male fetuses relative to their sex\u2010matched control groups. Prenatal BPA treatment also altered the postnatal growth trajectory in a sex\u2010specific manner. Males grew slower during the early postnatal period and caught up later. Females, in contrast, demonstrated the opposite growth trend. Prenatal BPA\u2010induced changes in fetal organ differentiation and early life growth strongly implicate translational relevance of in utero contributions to reproductive and metabolic defects previously reported in adult female offspring.<\/jats:p>","DOI":"10.1002\/jat.3836","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T00:25:02Z","timestamp":1563927902000},"page":"1516-1531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Developmental programming: Sex\u2010specific programming of growth upon prenatal bisphenol A exposure"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6256-5838","authenticated-orcid":false,"given":"Arpita Kalla","family":"Vyas","sequence":"first","affiliation":[{"name":"College of Medicine California Northstate University  Elk Grove California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almudena","family":"Veiga\u2010Lopez","sequence":"additional","affiliation":[{"name":"Department of Animal Science Michigan State University  East Lansing Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Ye","sequence":"additional","affiliation":[{"name":"Biostatistics Department School of Public Health  Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bachir","family":"Abi Salloum","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Michigan  Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Abbott","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Wisconsin National Primate Research Center University of Wisconsin  Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengping","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Pennington Biomedical Research Center  Baton Rouge Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyang","family":"Liao","sequence":"additional","affiliation":[{"name":"New York State Department of Health Wadsworth Center  Albany New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurunthachalam","family":"Kannan","sequence":"additional","affiliation":[{"name":"New York State Department of Health Wadsworth Center  Albany New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasantha","family":"Padmanabhan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Michigan  Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2013.02.011"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1559325815590395"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.01.025"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2004.10719428"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2009.11.007"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.08.021"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1409143"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1408258"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph10127001"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0800265"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5196958"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1205092"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-069X-10-94"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfq186"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.112.106369"},{"issue":"6","key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0026-895X(25)10133-8","article-title":"The inadequacy of perinatal glucuronidation: immunoblot analysis of the developmental expression of individual UDP\u2010glucuronosyltransferase isoenzymes in rat and human liver microsomes","volume":"34","author":"Coughtrie M. 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