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However, the role of exosomal miR\u2010221 in benzene\u2010caused carcinogenesis remains elusive. Our study was designed to investigate whether exosomes secreted by the hydroquinone (HQ; an active metabolite of benzene)\u2010transformed malignant cells can transmit miR\u2010221 to normal recipient cells and its possible effects on cell viability. Our investigation revealed that expression levels of miR\u2010221 were significantly increased in HQ\u2010transformed malignant cells relative to normal controls. Furthermore, exposure of control cells to exosomes that were derived from HQ\u2010transformed malignant cells increased miR\u2010221 levels and promoted their proliferation. Analyses of the biological potency of exosomes derived from HQ\u2010transformed malignant cells in which miR\u2010221 levels were decreased using an inhibitor, showed that both miR\u2010221 levels and proliferation of recipient cells were decreased, but still were higher than those of normal 16HBE cells. Our study indicates that exosomal miR\u2010221 derived from HQ\u2010transformed malignant human bronchial epithelial cells is involved in the proliferation of recipient cells.<\/jats:p>","DOI":"10.1002\/jat.3898","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T03:45:57Z","timestamp":1567136757000},"page":"224-233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Exosomal miR\u2010221 derived from hydroquinone\u2010transformed malignant human bronchial epithelial cells is involved in cell viability of recipient cells"],"prefix":"10.1002","volume":"40","author":[{"given":"Ran","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Environmental Health, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoyu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenwei","family":"Lian","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuqing","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Medicine Jiamusi University  Jiamusi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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