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This agent is incompletely removed by wastewater treatment and represents an environmental contaminant. Recent studies have shown that TCC is associated with some endocrine disruptions. The aim of the present study was to evaluate if TCC exposure during critical periods of development (gestation and lactation) could lead to adverse effects on reproductive and behavior parameters of female offspring. Pregnant female Wistar rats were divided into four groups (<jats:italic>n<\/jats:italic> = 8\u201311\/group): Control; TCC 0.3 mg\/kg (TCC 0.3); TCC 1.5 mg\/kg; TCC 3.0 mg\/kg (TCC 3.0); and treated daily by oral gavage from gestational day 0 to lactational day 21. The female pups (F1 generation) were weaned on post\u2010natal day 21 and included in the study. No litter\u2010mates were used for the same group. There was a decrease in estradiol levels in the TCC 0.3 and TCC 3.0 groups. Moreover, there was a decrease in progesterone levels and an increase in pre\u2010implantation loss in the TCC 3.0 group in adulthood. It is suggested, in this study, that the decrease in progesterone biosynthesis could interfere with implantation process. The exposure window to TCC is an important factor, as we found alterations only in the offspring.<\/jats:p>","DOI":"10.1002\/jat.3922","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T12:04:11Z","timestamp":1577102651000},"page":"504-514","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["In utero and lactational exposure to triclocarban: reproductive effects on female rat offspring"],"prefix":"10.1002","volume":"40","author":[{"given":"Nath\u00e1lia Orlandini","family":"Costa","sequence":"first","affiliation":[{"name":"Department of Physiological Sciences State University of Londrina  Londrina Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena Ireno","family":"Borges","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences State University of Londrina  Londrina Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liara Freitas","family":"Cavalcanti","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences State University of Londrina  Londrina Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno Garcia","family":"Montagnini","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences State University of Londrina  Londrina Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janete Aparecida","family":"Anselmo Franci","sequence":"additional","affiliation":[{"name":"Department of Morphology, Estomatology and Physiology University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina Inhasz","family":"Kiss","sequence":"additional","affiliation":[{"name":"Department of Physiology Botucatu Biosciences Institute, S\u00e3o Paulo State University  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8692-8007","authenticated-orcid":false,"given":"Daniela Cristina Ceccatto","family":"Gerardin","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences State University of Londrina  Londrina Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.11200"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056161"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(76)90254-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001860102"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2011.03.016"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-1057"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2010.09.031"},{"key":"e_1_2_7_9_1","unstructured":"Council T. personal care products. 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