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However, the inner mechanisms involved in the interactions are largely unknown. In this study, two commercial quantum dots (QDs), CdSe\/ZnS\u2010MPA and CdSe\/ZnS\u2010GSH, were tested for their interactions with P\u2010glycoprotein (P\u2010gp), as well as the relating mechanisms in lung cancer (A549) cells. Both QDs significantly suppressed the gene and protein expressions of P\u2010gp in A549 cells. To explain this, the gene expressions of nine relating microRNAs (miRNAs) were evaluated. The results indicated a shared up\u2010regulation of miR\u201034b and miR\u2010185 by both QDs. Furthermore, mimics and inhibitors of miR\u201034b and miR\u2010185 significantly enhanced and suppressed the gene and protein expressions of P\u2010gp, respectively, confirming the modulatory function of these two miRNAs on P\u2010gp. Interestingly, expressions of both miRNAs were suppressed during treatment with Cd<jats:sup>2+<\/jats:sup> and doxorubicin, which induced the expression of P\u2010gp, indicating the universality of these miRNAs\u2010related mechanisms. Thus, as miR\u201034b and miR\u2010185 participated in the suppression of P\u2010gp functions in A549 cells they could be interesting targets for the treatment of lung cancer.<\/jats:p>","DOI":"10.1002\/jat.3924","type":"journal-article","created":{"date-parts":[[2019,12,28]],"date-time":"2019-12-28T01:34:07Z","timestamp":1577496847000},"page":"525-534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["MicroRNA\u2010mediated suppression of P\u2010glycoprotein by quantum dots in lung cancer cells"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0946-8147","authenticated-orcid":false,"given":"Yimin","family":"Sun","sequence":"first","affiliation":[{"name":"University of Science and Technology of China  Hefei China"},{"name":"CAS Key Lab of Bio\u2010Medical Diagnostics Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6876-4734","authenticated-orcid":false,"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"CAS Key Lab of Bio\u2010Medical Diagnostics Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huancai","family":"Yin","sequence":"additional","affiliation":[{"name":"University of Science and Technology of China  Hefei China"},{"name":"CAS Key Lab of Bio\u2010Medical Diagnostics Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Yin","sequence":"additional","affiliation":[{"name":"University of Science and Technology of China  Hefei China"},{"name":"CAS Key Lab of Bio\u2010Medical Diagnostics Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences  Suzhou China"},{"name":"Shandong Guo Ke Medical Technology Development Co., Ltd  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21070886"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1168750"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2016.04.017"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp400596v"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161282005140214165212"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2003.11.023"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9TB01112A"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2002.02830.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-016-5059-1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.04.031"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp500099g"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2016.05.001"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.06.004"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.11.139"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10529-015-1941-y"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201700328"},{"key":"e_1_2_6_19_1","first-page":"295","article-title":"Overcoming PGP\u2010related multidrug resistance. 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