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Once the fine atmospheric particulate matter (FP) is inhaled, some of its compounds can pass through the lungs and reach the bloodstream where they can come into contact with immune cells. Exposure to FP particularly affects sensitive populations such as the elderly. Aging affects the immune system, making the elderly more vulnerable. The project aims to determine the effects of FP exposure on human T cells while looking for biomarkers associated with exposure. Blood samples from 95 healthy subjects in three different age groups (20\u201030, 45\u201055 and 70\u201085 years) were collected to determine a potential age effect. T lymphocytes were isolated to be exposed ex vivo for 72 hours to 45 \u03bcg\/mL of FP collected in Dunkirk and chemically characterized. Overexpression of the <jats:italic>CYP1A1<\/jats:italic>, <jats:italic>CYP1B1<\/jats:italic> and <jats:italic>CYP2S1<\/jats:italic> genes was therefore measured after exposure of the T cells to FP. 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