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Additionally, ET\u201026HCl showed similar hemodynamic stability as etomidate in the rat uncontrolled hemorrhagic shock model. Furthermore, ET\u201026HCl, in the rat lipopolysaccharide\u2010induced sepsis model, was found to have a higher survival rate, a lower inflammatory reaction, and less organ injury. In the present study, we measured the potential adverse effects of ET\u201026HCl in beagle dogs in accordance with the Guidance on single\u2010 and repeated\u2010dose toxicity published by the China Food and Drug Administration. In toxicity studies, single and repeated (14 days) intravenous doses of up to 16 mg\/kg were well tolerated, with only pharmacologically related clinical signs seen in both studies. Thus, the no\u2010observed\u2010adverse\u2010effect level (NOAEL) of ET\u201026HCl was found at 16 mg\/kg\/day. Toxicokinetic examination demonstrated that ET\u201026HCl showed a dose\u2010dependent increase to exposure, no gender difference, and no evidence of accumulation. These results provide useful information for guiding a phase I clinical trial of ET\u201026HCl in healthy volunteers.<\/jats:p>","DOI":"10.1002\/jat.3936","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T03:02:30Z","timestamp":1577070150000},"page":"679-690","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Preclinical safety evaluation of ET\u201026 hydrochloride, a novel intravenous anesthetic agent, in beagle dogs"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0419-5397","authenticated-orcid":false,"given":"YuJun","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Laboratory of Anesthesia and Critical Care Medicine, Translational Neuroscience Center, West China Hospital, Sichuan University  Chengdu Sichuan China"},{"name":"National\u2010Local Joint Engineering Research Center of Translational 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