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However, little has been known about how cadmium telluride (CdTe) QDs influence the gut microbiota and lipid metabolism. In this study, mice were exposed orally to CdTe QDs (200 \u03bcL of 0.2, 2, 20 or 200 \u03bc<jats:sc>m<\/jats:sc>; twice per week) for 4 weeks. The oral experiments showed CdTe QD exposure led to a decrease of the <jats:italic>Firmicutes<\/jats:italic>\/<jats:italic>Bacteroidetes<\/jats:italic> (F\/B) ratio of gut microbiota, which highly negatively correlated with the low\u2010density lipoprotein (LDL), triglyceride (TG) and total cholesterol (TC) levels in serum. In addition, the low\u2010dose (0.2 and 2 \u03bc<jats:sc>m<\/jats:sc>) CdTe QDs significantly increased the diversity of gut microbiota, and did not elevate the LDL, TG and TC levels in serum. The medium dose (20 \u03bc<jats:sc>m<\/jats:sc>) of CdTe QDs caused the biggest decrease of the F\/B ratio, so it significantly increased the LDL, TG and TC levels compared with the control. Furthermore, high\u2010dose (200 \u03bc<jats:sc>m<\/jats:sc>) CdTe QDs caused various toxicities in the histopathology of liver and intestine, liver function and intestinal immunity, but did not significantly lead to changes of the LDL, TG and TC levels in serum. This study demonstrates that high\u2010dose oral CdTe QDs mainly lead to tissue damage of the liver and intestine, while the medium and low doses of oral CdTe QDs induce shifts of gut microbiota structure, which are associated with blood lipid levels.<\/jats:p>","DOI":"10.1002\/jat.3972","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T06:30:06Z","timestamp":1584081006000},"page":"1131-1140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Gut microbiota and lipid metabolism alterations in mice induced by oral cadmium telluride quantum dots"],"prefix":"10.1002","volume":"40","author":[{"given":"Xiaohui","family":"Li","sequence":"first","affiliation":[{"name":"School of Geography and Biological Information Nanjing University of Posts and Telecommunications  Nanjing China"},{"name":"Key Laboratory for Organic Electronics and Information Displays &amp; Jiangsu Key Laboratory for 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