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Analyses of conventional treatments, such as radiotherapy and chemotherapy, have shown not only a lower therapeutic efficiency rate but also plethora of side\u2010effects. Considering the desperate need to identify promising anticancer agents, researchers are in quest to design and develop new tumoricidal drugs from natural sources. Over the past few years, scorpion venoms have shown exemplary roles as pivotal anticancer agents. Scorpion venoms associated metabolites, particularly toxins demonstrated <jats:italic>in vitro<\/jats:italic> anticancer attributes against diversified cell lines by inhibiting the growth and progression of the cell cycle, inhibiting metastasis by blocking ion channels such as K<jats:sup>+<\/jats:sup> and Cl<jats:sup>\u2212<\/jats:sup>, and\/or inducing apoptosis by intrinsic and extrinsic pathways. This review sheds light not only on <jats:italic>in vitro<\/jats:italic> anticancer properties of distinct scorpion venoms and their toxins, but also on their mechanism of action for designing and developing new therapeutic drugs in future.<\/jats:p>","DOI":"10.1002\/jat.3976","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T00:19:39Z","timestamp":1586132379000},"page":"1310-1324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Scorpion venoms and associated toxins as anticancer agents: update on their application and mechanism of action"],"prefix":"10.1002","volume":"40","author":[{"given":"Erasto","family":"Desales\u2010Salazar","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n y Estudios Avanzados en Salud Animal (CIESA), Facultad de Medicina Veterinaria y Zootecnia Universidad Aut\u00f3noma del Estado de M\u00e9xico (UAEM)  Toluca Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameer","family":"Khusro","sequence":"additional","affiliation":[{"name":"Research Department of Plant Biology and Biotechnology Loyola College  Nungambakkam, Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mois\u00e9s","family":"Cipriano\u2010Salazar","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Medicina Veterinaria y Zootecnia Universidad Aut\u00f3noma de Guerrero  Guerrero Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Barbabosa\u2010Pliego","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n y Estudios Avanzados en Salud Animal (CIESA), Facultad de Medicina Veterinaria y Zootecnia Universidad Aut\u00f3noma del Estado de M\u00e9xico (UAEM)  Toluca Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymundo Rene","family":"Rivas\u2010Caceres","sequence":"additional","affiliation":[{"name":"Autonomous University of Ciudad Ju\u00e1rez  Ciudad Ju\u00e1rez Chihuahua Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2018.07.008"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-2269-3"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobaz.2015.09.003"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2013.11.016"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2008.03.006"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2013.08.039"},{"key":"e_1_2_10_8_1","volume-title":"Manual de Enfermer\u00eda Oncol\u00f3gica","author":"Aibar S.","year":"2009"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.15430\/JCP.2017.22.1.40"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.4036"},{"key":"e_1_2_10_11_1","first-page":"49","article-title":"Effects of Leurus quinquestriatus scorpion venom on histological structure of the liver and kidney","volume":"3","author":"Al\u2010Harbi H. 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