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However, the role of exosomal secretion in the adaption of its source cells to the stimuli of environmental chemicals remains elusive. In this study, we revealed that the exposure of hydroquinone (HQ; the main bioactive metabolite of benzene) to human bronchial epithelial cells (16HBE) resulted in decreased ability of cell proliferation and migration, and simultaneously DNA damage and micronuclei formation. Interestingly, when exosomal secretion of HQ treated 16HBE cells was inhibited with the inhibitor GW4869, cellular proliferation and migration were further significantly reduced; concurrently, their DNA damage and micronuclei formation were both further significantly aggravated. Herein, we conclude that exosomal secretion of 16HBE cells may be an important self\u2010protective function against the toxic effects induced by HQ.<\/jats:p>","DOI":"10.1002\/jat.4043","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T23:26:32Z","timestamp":1595978792000},"page":"265-275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Exosomal secretion may be a self\u2010protective mechanism of its source cells under environmental stress: A study on human bronchial epithelial cells treated with hydroquinone"],"prefix":"10.1002","volume":"41","author":[{"given":"Zhonghan","family":"He","sequence":"first","affiliation":[{"name":"Shiyan Institute of Preventive Medicine and Health Care  Shenzhen City China"},{"name":"Department of Environmental Health, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health Southern Medical University  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