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Due to a considerably long biological half\u2010life and very low rate of excretion, accumulation of Cd in different body organs (eg, liver, kidney, and testes) over time is associated with perturbed functioning of these organs. Recent studies have shown the extreme sensitivity of the testes to Cd toxicity. In testes, Cd has been reported to induce oxidative stress, apoptosis of spermatogenic cells, reduction in androgen production and sperm functions. Moreover, Cd in combination with other environmental toxicants may be responsible for the declining fertility of males in both animals and humans. Pinpointing how Cd toxicity affects various testicular processes will be imperative for the development of preventative measures to promote fertility among males. Therefore, in the present review, we summarize the recent findings related to the Cd\u2010induced oxidative toxicity, apoptotic toxicity, steroidogenic toxicity, and spermatotoxicity, along with their possible mechanisms in testicular tissue of different animal species. In addition, the utilization of various antioxidant compounds, medicinal plants and other compounds for the management of Cd toxicity in testes is discussed.<\/jats:p>","DOI":"10.1002\/jat.4055","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T08:31:12Z","timestamp":1599035472000},"page":"105-117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":136,"title":["Cadmium as a testicular toxicant: A Review"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2183-3058","authenticated-orcid":false,"given":"Jitender Kumar","family":"Bhardwaj","sequence":"first","affiliation":[{"name":"Reproductive Physiology Laboratory, Department of Zoology Kurukshetra University  Kurukshetra Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish","family":"Panchal","sequence":"additional","affiliation":[{"name":"Reproductive Physiology Laboratory, Department of Zoology Kurukshetra University  Kurukshetra Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Saraf","sequence":"additional","affiliation":[{"name":"Reproductive Physiology Laboratory, Department of Zoology Kurukshetra University  Kurukshetra Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.repbio.2016.11.001"},{"issue":"1","key":"e_1_2_6_3_1","first-page":"17","article-title":"Cadmium toxicity: a possible cause of male infertility in Nigeria","volume":"6","author":"Akinloye O.","year":"2006","journal-title":"Reproductive Biology"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-019-02016-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.4928"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19123979"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-019-01736-w"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1262\/jrd.18110"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0900975"},{"key":"e_1_2_6_10_1","unstructured":"ATSDR. 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